Description

Evermil 10 mg (Everolimus): Dual‑Role mTOR Inhibitor for Oncology & Transplant Therapy

Evermil 10 mg tablet contains everolimus, a mammalian-target-of-rapamycin (mTOR) kinase inhibitor marketed in India as a branded generic of Afinitor. Everolimus interrupts mTOR➡cell growth pathways and suppresses immune activation—making it effective in certain cancers and transplant medicine. 

✅ Therapeutic Uses & Standard Dosing

• Breast cancer (HR+, HER2−): 10 mg once daily with exemestane after failure of aromatase inhibitors. 
• Renal cell carcinoma (RCC): 10 mg once daily after VEGF-targeted therapy.
• Advanced neuroendocrine tumors (pNET, GI, lung): 10 mg daily until progression or toxicity. 
• TSC-related tumors (SEGA, angiomyolipoma): 10 mg daily adults; pediatric/seizure dose based on 4.5 mg/m² with therapeutic monitoring.
• Transplant rejection prophylaxis: 0.75–1 mg twice daily started ≥30 days post‑kidney or liver transplant with calcineurin inhibitor taper. Dose adjustments via drug levels. 

⚠️ Common Side Effects & Monitoring

• **Stomatitis / oral ulcers** (≥ 30%)—managed proactively with water-based dexamethasone mouthwash. 
• Frequent: infections, fatigue, rash, diarrhea, edema, hyperglycemia, hyperlipidemia, anemia, lymphopenia.
• Serious: non-infectious pneumonitis, renal impairment, metabolic disturbances, rare cardiac failure or severe infection in transplant users. 

🚨 Precautions & Drug Interactions

• Require baseline and periodic labs: CBC, LFTs, renal panel, lipids, fasting glucose. Monitor for pneumonitis. 
• Avoid live vaccines during and months post-therapy. 
• Watch for potent CYP3A4/P-gp inhibitors (e.g., ketoconazole, grapefruit juice)—avoid or dose-reduce. Inducers (e.g., rifampin) may require dose adjustments. (
• Caution in pregnancy and breastfeeding—teratogenic risk; effective contraception for both genders. 

📍 Why Choose Evermil 10 mg?

• Branded generic offers similar efficacy to Afinitor at significantly lower cost.
• Once-daily dosing simplifies long-term outpatient use. Suitable for both cancer and transplant patients. 
• Recognized essential medicine worldwide. 

❓ Frequently Asked Questions (FAQs)

1. May I take Evermil with food?

Yes—Evermil may be taken consistently with or without food; stick to one pattern daily for steady absorption. 

2. What should I do if I miss a dose?

If less than 8 hrs late, take it; if more, skip and take the next dose at the usual time. Do not double up. 

3. How long is treatment continued?

In cancer, therapy is typically continued until disease progression or intolerable toxicity. In transplant cases, Evermil may be continued long-term under therapeutic monitoring.

4. Is Evermil safe in elderly patients?

Yes—with dose adjustments and close monitoring for renal function, blood counts, and metabolic parameters.

5. May I drink grapefruit juice or take strong enzyme inhibitors?

No—these can greatly increase everolimus levels and risk toxicity. Avoid grapefruit juice and notify your doctor of all herbal supplements.