Description

Signapred 4 mg (Methylprednisolone) – Low‑Dose Oral Steroid for Inflammation & Allergic Relief

Signapred 4 mg contains methylprednisolone, a low-dose synthetic glucocorticoid commonly used for acute flares of allergic conditions, rheumatic pain, skin disorders, lupus, gout, and ocular inflammation. It works by suppressing inflammatory cytokine production and modulating immune response. 

🔹 Therapeutic Uses

• Treats allergic reactions such as urticaria, angioedema, asthma exacerbations, and serum sickness. 
• Manages autoimmune and rheumatic diseases (e.g., lupus, rheumatoid arthritis).
• Controls inflammatory skin conditions like eczema, psoriasis; eye inflammation like uveitis, scleritis, conjunctivitis.
• Helps relieve pain and swelling during acute gout flares when NSAIDs or colchicine aren’t suitable. 

⚙️ Mechanism of Action

Methylprednisolone binds to glucocorticoid receptors to inhibit inflammatory gene transcription and reduce leukocyte migration. With a rapid onset, effects typically begin within hours. 

🩺 Dosage & Administration (Typical for Adults)

• Maintenance dose: 4 mg once daily, usually in the morning with food. Total dose may vary from 4 mg to 48 mg/day based on condition severity. 
• Administer **with meals** to reduce GI irritation. Swallow whole—do not crush or chew. 
• For long-term use (>2 weeks), taper dose gradually to avoid adrenal insufficiency. 

❗ Side Effects & Monitoring

• Common: upset stomach, headache, mood changes (insomnia, anxiety), fluid retention, hypertension, hyperglycemia in diabetic patients. 
• With prolonged use: skin thinning, osteoporosis, weight gain, muscle weakness, impaired wound healing, cataracts or ↑ IOP, Cushingoid features. 
• Long-term suppression of adrenal axis may occur—monitor symptoms if used for >10–14 days; taper as prescribed. 

⚠ Warnings & Interactions

• Contraindicated in systemic fungal infections and known hypersensitivity to methylprednisolone.
• Use cautiously in: diabetes, hypertension, osteoporosis, peptic ulcer disease, psychiatric disorders, glaucoma, and liver or kidney disease.
• Avoid live vaccines during therapy due to immunosuppression. ([turn0search0])
• Significant drug interactions with CYP3A4 inhibitors/inducers (e.g. ketoconazole, phenytoin), anticoagulants, NSAIDs, hypoglycemic agents—monitor and adjust as needed. 

🧬 Why Choose Signapred 4 mg?

• Low 4 mg tablet combines efficacy with reduced side effects—ideal for short-term flare management. 
• Single, scored 4 mg tablet allows precise dosing adjustments and easier tapering.
• Affordable Indian generic by HAB Pharma, readily available in branded and price-constrained markets. 

❓ Frequently Asked Questions (FAQs)

1. Can I stop Signapred suddenly?

No—abrupt stopping, especially after more than 2 weeks of use, risks adrenal insufficiency. Always taper slowly according to your doctor’s plan. 

2. What if I miss a dose?

Take it as soon as you remember if it’s more than 12 hours before your next dose. Otherwise, skip it—never double up. 

3. How soon will I feel relief?

Many patients experience symptom improvement within hours to 1–2 days, especially for acute allergy or gout flares. Full benefits may take several days depending on condition. 

4. Do I need blood tests while using it?

Short-term use typically doesn’t require labs. If treatment extends beyond a few weeks, monitor blood pressure, blood sugar, electrolytes, bone density, and signs of infection. 

5. Can I take Signapred during pregnancy or breastfeeding?

Discuss with your physician—methylprednisolone crosses placenta and excreted in breastmilk. Risk vs benefit should be carefully evaluated.