Apigat 5 mg (Apixaban)
Apigat 5 mg contains apixaban, an oral direct Factor Xa inhibitor (DOAC) used to prevent stroke and systemic embolism in non-valvular atrial fibrillation and to treat and prevent venous thromboembolism (VTE). Apixaban is prescription-only; initiation and monitoring should be supervised by a clinician experienced in anticoagulation.
Apigat provides predictable anticoagulation with fixed dosing for many indications and generally does not require routine laboratory monitoring; however, renal function, bleeding risk and interacting medicines must be reviewed before starting.
Product introduction
Apixaban selectively and reversibly inhibits Factor Xa, reducing thrombin generation and thrombus formation. The 5 mg tablet is the standard maintenance dose for many adult indications, including stroke prevention in atrial fibrillation and ongoing treatment after the initial intensive phase for VTE.
Uses of Apigat 5 mg (Apixaban)
Common indications (specialist-directed):
- Prevention of stroke and systemic embolism in adults with non-valvular atrial fibrillation — usual dose 5 mg twice daily for most patients.
- Treatment of acute DVT and PE — typically initial higher-intensity dosing followed by 5 mg twice daily as the maintenance phase. :contentReference[oaicite:5]{index=5}
- Reduction in the risk of recurrent DVT/PE after initial treatment (maintenance dosing).
- Thromboprophylaxis in selected medically ill or orthopaedic patients (different lower dosing regimens apply).
Note: Indication-specific regimens differ — follow local product information and your prescriber’s instructions.
Benefits of Apigat 5 mg (Apixaban)
- Oral fixed dosing: no routine INR monitoring required for most patients.
- Rapid onset: achieves anticoagulant effect soon after dosing.
- Evidence-based: proven efficacy for stroke prevention in AF and for VTE treatment and prevention.
Side effects of Apigat 5 mg (Apixaban)
The principal adverse effect is bleeding; other side effects are less common.
Common side effects
- Minor bleeding (bruising, epistaxis)
- Gastrointestinal bleeding
- Anemia from blood loss
Serious risks: major or life-threatening bleeding (including intracranial or GI haemorrhage). Seek urgent medical attention for severe bleeding, fainting, sudden severe headache, weakness, or black/tarry stools. Combining apixaban with antiplatelet drugs or strong CYP3A4/P-gp inhibitors increases bleeding risk.
How to use Apigat 5 mg (Apixaban)
- For stroke prevention in non-valvular AF the recommended dose for most adults is 5 mg orally twice daily. Do not alter dose without clinician advice.
- For treatment of acute DVT/PE the typical regimen often begins with higher initial dosing and then continues with 5 mg twice daily as maintenance—follow your prescriber.
- Swallow tablets whole with water; may be taken with or without food (take ≥15 mg doses with food when labelled). Maintain adherence—missed doses increase thrombotic risk.
- If a dose is missed, take it as soon as remembered on the same day; do not double doses. Contact your clinician if multiple doses are missed.
- Inform all healthcare providers (surgeons, dentists) that you are taking apixaban — peri-procedural management should be coordinated with clinicians.
How Apigat works
Apixaban directly inhibits Factor Xa, decreasing conversion of prothrombin to thrombin, thereby reducing fibrin clot formation. Its predictable pharmacokinetics allow fixed dosing without routine coagulation monitoring for most patients.
Safety advice
| Pregnancy / Breastfeeding | Apixaban is generally avoided in pregnancy; consult a specialist. Limited data in breastfeeding — discuss risks with your clinician. |
| Renal impairment | Dosing considerations apply in renal impairment — adjust per product labeling and clinician advice. Use caution in severe renal dysfunction. |
| Hepatic impairment | Use caution or avoid in significant hepatic disease associated with coagulopathy and clinically relevant bleeding risk. Specialist guidance required. |
| Drug interactions | Apixaban is a substrate of CYP3A4 and P-gp. Strong dual inhibitors (ketoconazole, ritonavir) or inducers (rifampicin, carbamazepine) may alter levels—review all medicines and supplements with your prescriber. : |
| Reversal | For life-threatening bleeding, andexanet alfa (where available) is an approved reversal agent for apixaban; where unavailable, prothrombin complex concentrates (PCCs) and supportive measures may be used — manage in hospital. |
What if you forget to take Apigat?
- Take the missed dose the same day if you remember; for twice-daily regimens do not take two doses at once. Resume the usual schedule the following day. If in doubt, contact your clinician.
All substitutes
Other oral anticoagulants and strategies include:
- Other DOACs (apixaban alternatives: rivaroxaban, dabigatran, edoxaban) — choice depends on indication and patient factors.
- Low molecular weight heparin (LMWH) for selected perioperative or pregnancy indications.
- Vitamin K antagonists (warfarin) where monitoring and reversal strategies are preferred.
Selection should be individualised by the treating clinician.
Quick tips
- Carry an anticoagulation card and inform all care providers that you take apixaban.
- Avoid OTC NSAIDs and unnecessary antiplatelet agents unless advised—they increase bleeding risk.
- Keep an updated list of medicines and supplements for interaction checks.
- Report any signs of bleeding or sudden neurologic symptoms immediately.
Fact Box
| Generic name | Apixaban |
| Brand | Apigat 5 mg |
| Drug class | Oral direct Factor Xa inhibitor (DOAC) |
| Form | Oral tablet (5 mg) |
| Typical AF dosing | 5 mg twice daily (reduce to 2.5 mg twice daily if ≥2 of: age ≥80, weight ≤60 kg, serum creatinine ≥1.5 mg/dL). |
| Typical VTE maintenance | 5 mg twice daily after initial intensive phase (see product label). |
| Prescription | Required — specialist/physician supervision |
Patient concerns
Will Apigat completely prevent clots? No anticoagulant eliminates all risk. Apixaban significantly reduces risk in indicated settings, but adherence and clinician follow-up are essential.
What if I need surgery? Inform your surgical team—temporary interruption is often necessary and timing depends on bleeding risk and renal function. Do not stop without clinician advice.
User feedback
Patients frequently report convenience with oral dosing and less need for monitoring versus warfarin. Bleeding remains the principal concern—education and rapid access to medical care for suspected bleeding are important.
Are you currently taking Apigat 5 mg? Let us know how it is working for you by taking this survey.
FAQs
Can I take Apigat with aspirin?
Combining apixaban with antiplatelet agents increases bleeding risk. Only take concomitant antiplatelet therapy if specifically advised by your clinician (e.g., after stenting).
Is there an antidote for Apigat?
Yes — andexanet alfa is an approved reversal agent for apixaban in many regions for life-threatening bleeding; other options such as PCCs and supportive measures may be used where andexanet is unavailable. Manage urgently in hospital.
How should I store Apigat?
Store at room temperature away from moisture and heat. Keep out of reach of children and do not use past the expiry date.
Related products
- Other DOACs (rivaroxaban, dabigatran, edoxaban)
- LMWH for inpatient or pregnancy indications
- Compression stockings and mechanical prophylaxis where indicated
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Disclaimer:
This content is educational only and does not replace professional medical advice. Apigat (apixaban) must be prescribed and monitored by qualified clinicians. For specific guidance follow your treating clinician and the product label.
References
- ELIQUIS (apixaban) Prescribing Information — FDA label.
- ELIQUIS dosing guides and orthopaedic prophylaxis information.
- Reversal guidance — Andexanet alfa (andexanet) literature & guidance.
- StatPearls / NCBI overview of apixaban pharmacology and dosing.
Marketer details
genericurerx — support@genericurerx.com — www.genericurerx.com
In case of any issues, contact us
For ordering or prescription verification use live chat or our contact page. For medical concerns contact your treating clinician immediately.
Lab tests offered by us
- Renal function tests (baseline & as indicated)
- Hemoglobin / CBC if bleeding suspected
- Specialist coagulation advice and peri-procedural planning
Additional offers
Prescription coordination, anticoagulation counselling and monitoring support available on request. Use code GLOBAL10 where eligible for first-order discounts.
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