Bemdac 180 mg (Bempedoic acid)
Bemdac 180 mg contains bempedoic acid, an oral ATP-citrate lyase (ACL) inhibitor indicated to further lower low-density lipoprotein cholesterol (LDL-C) in adults who require additional LDL-C reduction despite maximally tolerated statin therapy, or in patients who are statin-intolerant where additional non-statin LDL-C lowering is needed. Bempedoic acid is typically used as an adjunct to other lipid-lowering strategies under clinician guidance.
Bemdac 180 mg is a once-daily tablet formulation designed to be taken in combination with other lipid-lowering therapies when appropriate.
Product introduction
Bempedoic acid inhibits ATP-citrate lyase, an enzyme upstream of HMG-CoA reductase in the cholesterol biosynthesis pathway, reducing hepatic cholesterol synthesis and upregulating LDL receptors which increase LDL-C clearance. It is a prodrug that requires activation primarily in the liver, limiting exposure in skeletal muscle and thereby reducing the likelihood of muscle-related adverse effects compared with some statins in susceptible individuals.
Uses of Bemdac 180 mg (Bempedoic acid)
Common clinical uses include:
- As add-on therapy to maximally tolerated statin therapy for additional LDL-C lowering.
- For patients with atherosclerotic cardiovascular disease (ASCVD) or heterozygous familial hypercholesterolaemia (HeFH) needing further LDL-C reduction.
- As an alternative lipid-lowering option for patients intolerant of statins (under specialist supervision).
Note: Treatment decisions (monotherapy vs combination therapy and target LDL goals) should be individualised by your clinician based on cardiovascular risk and laboratory results.
Benefits of Bemdac 180 mg
- Meaningful LDL-C reduction: provides additional lowering of LDL-cholesterol when added to standard therapy.
- Oral once-daily dosing: convenient for outpatient use.
- Low muscle exposure: liver-selective activation reduces the potential for muscle toxicity in many patients.
- Complements existing therapy: can be used with statins, ezetimibe and PCSK9 inhibitors as directed by clinicians.
Recommended dosing
The usual adult dose is 180 mg once daily. Take at the same time each day, with or without food. Do not change dose or stop treatment without consulting your prescribing clinician.
Side effects of Bemdac 180 mg
Adverse effects are generally modest but some require monitoring.
Common side effects
- Increased blood uric acid (hyperuricemia)
- Gout (in susceptible patients)
- Muscle spasms
- Gastrointestinal symptoms (constipation, abdominal pain)
- Elevated liver enzymes (transaminases) in some patients
- Increased risk of tendon symptoms (rare) — report new tendon pain
Important: Hyperuricaemia and gout flares are recognised risks—people with a history of gout should have uric-acid levels monitored and discuss risks with their clinician. Seek immediate medical attention for severe muscle pain, unexplained weakness, dark urine, signs of liver injury (jaundice, severe abdominal pain), or acute gout attacks.
How to use Bemdac 180 mg
- Take one 180 mg tablet once daily at the same time each day.
- It can be taken with or without food—swallow whole with water.
- Continue taking other prescribed lipid-lowering medications unless your clinician advises a change.
- Attend regular follow-up appointments and blood tests as recommended (lipid panel, liver function, uric acid where indicated).
- Do not stop suddenly without discussing with your clinician—changes in therapy should be supervised.
How Bemdac works
Bempedoic acid inhibits ATP-citrate lyase in the hepatic cholesterol biosynthesis pathway, reducing production of cholesterol in the liver and increasing LDL-receptor expression which leads to greater clearance of LDL-cholesterol from the bloodstream.
Safety advice
| Gout / hyperuricaemia | Monitor uric acid in patients at risk. Consider baseline uric-acid assessment and monitor for gout flares; manage per usual gout guidance. |
| Liver function | Check baseline liver enzymes (ALT/AST) and monitor during therapy if clinically indicated—stop or adjust therapy if significant liver injury occurs. |
| Muscle symptoms | Although bempedoic acid is activated mainly in the liver, report unexplained muscle pain or weakness; combine caution if used with high-dose statins or other myotoxic agents. |
| Drug interactions | May interact with certain lipid-lowering agents or drugs affecting conjugation pathways—inform your clinician of all medicines, supplements and herbal products. Clinicians may adjust concomitant statin dosing in some situations; always follow professional guidance. |
| Pregnancy & breastfeeding | Safety in pregnancy and breastfeeding is not established—use only if clearly needed and after specialist discussion; effective contraception is advised for women of childbearing potential unless otherwise counselled. |
What if you forget a dose?
- If you miss a dose, take it as soon as you remember on the same day.
- If it is almost time for the next dose, skip the missed dose and resume the usual schedule.
- Do not double doses to make up for a missed one.
All substitutes
Alternative or complementary lipid-lowering strategies include:
- Maximally tolerated statin therapy (atorvastatin, rosuvastatin)
- Ezetimibe (intestinal cholesterol-absorption inhibitor)
- PCSK9 inhibitors (injectable monoclonal antibodies or siRNA agents) for high-risk or refractory cases
- Bile-acid sequestrants or niacin in selected patients (specialist decision)
Quick tips
- Check fasting lipid panel 4–12 weeks after initiation or dose change to assess response.
- If you have gout or high uric acid, discuss prophylaxis or monitoring plans with your prescriber.
- Bring an updated medicines list to all visits—drug combinations may require dose adjustments.
- Report any new muscle pain, tendon pain, jaundice, or signs of inflammation promptly.
Fact Box
| Generic name | Bempedoic acid |
| Brand | Bemdac 180 mg |
| Drug class | ATP-citrate lyase (ACL) inhibitor — oral lipid-lowering agent |
| Form | Oral tablet (180 mg) |
| Typical dosing | 180 mg once daily |
| Prescription | Required — lipid specialist or prescribing clinician oversight recommended |
Patient concerns
Will Bemdac replace my statin? Not usually. Bempedoic acid is most often used in addition to maximally tolerated statins to achieve LDL-C targets, or as an option when statins cannot be tolerated. Your clinician will advise the best regimen for your risk profile.
How quickly will LDL-C fall? LDL-C reductions are usually seen within weeks; clinicians typically recheck lipid panels 4–12 weeks after starting to judge response and adjust therapy.
User feedback
Many patients prescribed bempedoic acid report meaningful LDL-C reductions when used in combination with other lipid-lowering medicines. Common concerns reported include gout flares in those predisposed and mild gastrointestinal or muscle-related symptoms—these are usually manageable with monitoring and clinician support.
FAQs
Can I take Bemdac with my statin?
Yes—bempedoic acid is commonly prescribed as an add-on to statin therapy when further LDL-C lowering is required. Your clinician will consider any interaction risk and may adjust doses if needed.
Do I need blood tests while on Bemdac?
Your prescriber will typically check lipid levels to confirm effect and may monitor liver function and uric acid in patients at risk of hyperuricaemia. Follow your clinician’s advised monitoring schedule.
How should I store Bemdac?
Store at room temperature away from moisture and heat. Keep out of reach of children and do not use past the expiry date.
Related products
- Atorvastatin, Rosuvastatin (statins)
- Ezetimibe
- PCSK9 inhibitors (e.g., evolocumab, alirocumab)
- Lipid panel testing services
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Disclaimer:
This information is for educational purposes only and does not replace medical advice. Bemdac (bempedoic acid) must be prescribed and monitored by a qualified clinician. Follow local product labeling and prescriber instructions.
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Lab tests offered by us
- Fasting lipid panel
- Serum uric acid
- Kidney & liver function tests
Additional offers
Prescription coordination and lipid management support available on request. Use code GLOBAL10 where eligible for first-order discounts.
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