Nebicard-H (Nebivolol 5 mg / Hydrochlorothiazide 12.5 mg)
Nebicard-H (Nebivolol 5 mg / HCTZ 12.5 mg) is a fixed-dose combination tablet that pairs nebivolol — a highly selective β1-adrenergic blocker with nitric-oxide–mediated vasodilatory properties — with hydrochlorothiazide (HCTZ), a low-dose thiazide diuretic. The combination is indicated for the management of essential hypertension when monotherapy is insufficient or when a beta-blocker plus diuretic is an appropriate treatment choice.
Nebicard-H combines complementary mechanisms: nebivolol reduces heart rate and cardiac output and adds vasodilation, while HCTZ reduces plasma volume and peripheral resistance — together producing effective blood-pressure lowering with once-daily dosing.
Product introduction
Nebivolol is a β1-selective blocker with endothelium-dependent vasodilatory action (increases nitric oxide), which may improve peripheral perfusion and metabolic profile versus older non-selective beta-blockers. Hydrochlorothiazide at 12.5 mg is a commonly used low-dose thiazide that provides diuretic and antihypertensive effects with a generally favourable tolerability profile. The fixed combination simplifies therapy and may improve adherence.
Uses of Nebicard-H (Nebivolol/HCTZ)
Typical clinical uses:
- Essential hypertension requiring combination therapy
- Patients not controlled on nebivolol or HCTZ monotherapy
- Combination treatment when a β-blocker + diuretic strategy is selected by the prescriber
Note: Use should be guided by a prescriber who will individualise therapy based on blood-pressure goals, comorbidities and other medications.
Benefits of Nebicard-H
- Once-daily convenience: simplified regimen improves adherence.
- Complementary mechanisms: combined haemodynamic and diuretic effects enhance BP control.
- Vasodilatory action: nebivolol’s NO-mediated vasodilation may reduce peripheral resistance without large metabolic penalties.
- Low-dose thiazide: 12.5 mg HCTZ balances efficacy and tolerability for many patients.
Recommended dosing
Typical dosing information (prescriber-directed):
- Standard adult dose: one tablet once daily (nebivolol 5 mg / HCTZ 12.5 mg).
- Take at the same time each day, with or without food.
- Do not split, crush or chew the tablet unless directed by your pharmacist.
- Adjustments: prescribers may alter therapy (separate components or different doses) depending on blood-pressure response, heart rate and tolerability.
Side effects of Nebicard-H
Adverse effects reflect both nebivolol and hydrochlorothiazide components.
Common side effects
- Dizziness or lightheadedness (especially on standing)
- Fatigue or tiredness
- Headache
- Bradycardia (slow heart rate)
- Increased urination / mild dehydration (from HCTZ)
- Electrolyte changes (low sodium, low potassium in some patients)
Important risks: symptomatic hypotension, marked bradycardia, significant electrolyte disturbance (hyponatraemia, hypokalaemia), gout flare (HCTZ can raise uric acid), and rare allergic reactions. Seek urgent medical attention for fainting, chest pain, severe dizziness, marked leg swelling, or signs of severe electrolyte imbalance (muscle weakness, severe cramps, irregular heartbeat).
How to use Nebicard-H
- Take exactly as directed by your doctor — typically one tablet once daily.
- Preferably take at the same time each day to maintain steady blood levels.
- Measure and record home blood pressures during initiation and dose changes; report symptomatic low BP or slow pulse to your clinician.
- Maintain adequate fluid intake, especially in hot weather or if exercising vigorously — thiazides increase fluid loss.
- Do not stop suddenly — abrupt withdrawal of beta-blockers can precipitate angina or rebound hypertension; taper under supervision if discontinuing.
How Nebicard-H works
Nebivolol selectively blocks β1 receptors to reduce heart rate and myocardial oxygen demand, and also enhances nitric-oxide availability causing peripheral vasodilation. Hydrochlorothiazide reduces blood volume by increasing renal sodium and water excretion and lowers peripheral resistance with chronic use. Together these effects lower systemic blood pressure through complementary pathways.
Safety advice
| Pregnancy | Avoid if possible — discuss with your prescriber. Some antihypertensives can harm the fetus; use only if clearly needed and after specialist advice. |
| Breastfeeding | Use with caution — components may pass into breastmilk; discuss risks/benefits with your clinician. |
| Asthma / COPD | Although nebivolol is β1-selective, caution is recommended in reactive airway disease — consult your prescriber. |
| Diabetes | Beta-blockers may mask symptoms of hypoglycaemia (e.g., tachycardia). Monitor blood glucose carefully and inform your diabetes team of therapy changes. |
| Kidney / liver disease | Use with caution and dose-adjust as advised — HCTZ effectiveness and electrolyte effects depend on renal function. |
| Electrolytes & uric acid | Monitor serum electrolytes (sodium, potassium) and uric acid where indicated — thiazides may decrease potassium and increase uric acid. |
| Drug interactions | Exercise caution with other antihypertensives, antiarrhythmics, certain antidepressants, lithium, NSAIDs (may blunt diuretic/antihypertensive effect) and drugs that affect potassium. Always provide a full medicines list to your prescriber/pharmacist. |
What if you forget a dose?
- Take the missed dose as soon as you remember the same day.
- If it is almost time for the next dose, skip the missed dose — do not double up.
- If you miss several doses or are unsure, contact your prescriber for advice.
All substitutes
Equivalent therapeutic strategies selected by prescribers may include:
- Separate nebivolol and hydrochlorothiazide tablets (individualised dosing)
- Other β-blocker + thiazide combinations (e.g., bisoprolol + thiazide) depending on comorbidities
- Other combination antihypertensives: ARB + thiazide, ACE inhibitor + diuretic, CCB + diuretic
Quick tips
- Take at the same time every day for consistent control.
- Check blood pressure and pulse regularly during the first weeks of therapy.
- Avoid sudden changes in posture to reduce dizziness (rise slowly from sitting/lying).
- Limit alcohol — it can increase blood-pressure lowering and dizziness.
- Avoid potassium supplements or potassium-sparing diuretics unless instructed — HCTZ can affect potassium balance.
- Inform your dentist/surgeon you take a beta-blocker before procedures.
Fact Box
| Generic names | Nebivolol / Hydrochlorothiazide |
| Brand | Nebicard-H (Nebivolol 5 mg / HCTZ 12.5 mg) |
| Drug class | β1-selective blocker (vasodilating) + thiazide diuretic |
| Form | Oral tablet (fixed-dose combination) |
| Typical dose | One tablet once daily (nebivolol 5 mg / HCTZ 12.5 mg) or as prescribed |
| Prescription | Required — clinician supervision and periodic monitoring |
Patient concerns
Will Nebicard-H control my blood pressure immediately? Some BP lowering may be noticed within hours–days, but full therapeutic effect is assessed over weeks. Continue therapy and attend follow-up to allow dose optimisation.
Can I drive while taking Nebicard-H? Many people can drive, but if you experience dizziness or fatigue after starting therapy, avoid driving until you know how the medicine affects you.
User feedback
Patients commonly report good blood-pressure control and appreciate once-daily dosing. Some report early fatigue or lightheadedness which often improves after the first few weeks. Patients with gout history may notice changes in uric-acid levels and should discuss this with their clinician.
FAQs
Can I take Nebicard-H with diabetes medications?
Yes, but beta-blockers can mask some symptoms of low blood sugar (tachycardia). Monitor glucose and discuss adjustments with your diabetes care team.
Do I need blood tests while on Nebicard-H?
Your clinician may check electrolytes, kidney function and blood pressure periodically — especially soon after starting or when other drugs are added.
How should I store Nebicard-H?
Store at room temperature away from moisture and heat. Keep out of reach of children and do not use past the expiry date.
Related products
- Nebivolol 5 mg (monotherapy)
- Thiazide diuretic monotherapies (HCTZ 12.5 mg)
- Other combination antihypertensives (ARB/HCTZ, ACEi/HCTZ, CCB/HCTZ)
Want to share the information?
Share this article to help patients and caregivers understand Nebicard-H therapy and safe use.
Disclaimer:
This article is for educational purposes only and does not replace personalised medical advice. Nebicard-H (nebivolol/hydrochlorothiazide) must be prescribed and monitored by a qualified clinician. Do not change or stop treatment without consulting your healthcare provider.
Marketer details
genericurerx — support@genericurerx.com — www.genericurerx.com
In case of any issues, contact us
For order or prescription verification use live chat or our contact page. For medical concerns contact your treating clinician immediately.
Lab tests offered by us
- Blood pressure monitoring
- Electrolyte panel (sodium, potassium)
- Kidney function tests (creatinine, eGFR)
- Uric acid testing if history of gout
Additional offers
Prescription coordination, adherence support and blood-pressure coaching available on request. Use code GLOBAL10 where eligible for first-order discounts.
Reviews
There are no reviews yet.