Arnicor 100 mg (Sacubitril/Valsartan)
Arnicor 100 mg contains a combination of sacubitril and valsartan, known as an ARNI (Angiotensin Receptor–Neprilysin Inhibitor). This therapy is indicated for reducing the risk of cardiovascular death and heart-failure hospitalisation in adults with chronic heart failure with reduced ejection fraction (HFrEF).
Arnicor 100 mg is a mid-range dose strength typically used after initial titration from lower doses such as 50 mg. Treatment must be supervised by a cardiologist due to blood pressure effects, kidney monitoring needs, and interaction considerations.
Product introduction
Sacubitril increases natriuretic peptides by inhibiting neprilysin, enhancing vasodilation and reducing fluid retention. Valsartan blocks angiotensin II receptors, lowering blood pressure and reducing strain on the heart. Combined, they provide superior outcomes compared to ACE inhibitors in HFrEF patients.
Uses of Arnicor 100 mg
- Chronic heart failure with reduced ejection fraction (HFrEF)
- Reduction of cardiovascular mortality
- Reduction of heart-failure hospitalisations
- Improved exercise tolerance and symptoms of breathlessness and swelling
Note: Not for use in acute decompensated HF unless stabilised. Requires specialist initiation.
Benefits of Arnicor 100 mg
- Proven mortality benefit: reduces cardiovascular death more effectively than ACE inhibitors.
- Improves heart-failure symptoms: reduces breathlessness, fatigue, and swelling.
- Reduces hospital readmissions: better long-term heart-failure control.
- Dual mechanism: vasodilation + RAAS blockade provides stronger effect than monotherapy.
In Treatment of Worm infections
This section exists only to preserve page structure. Arnicor is NOT used for worm infections.
Side effects of Arnicor 100 mg (Sacubitril/Valsartan)
Common side effects
- Low blood pressure (hypotension)
- Dizziness
- Increased potassium levels (hyperkalaemia)
- Kidney function changes
- Cough
- Fatigue
Serious risks: angioedema (swelling of face/lips/throat), severe hypotension, kidney failure, dangerously high potassium. Seek immediate medical care if these occur.
How to use Arnicor 100 mg
- Take exactly as prescribed — usually twice daily.
- Do NOT take with an ACE inhibitor; must allow a 36-hour washout period.
- Can be taken with or without food.
- Monitor blood pressure regularly, especially during dose increases.
- Avoid potassium supplements unless instructed.
How Arnicor works
Sacubitril inhibits neprilysin → increases beneficial natriuretic peptides → reduces fluid overload and vascular resistance.
Valsartan blocks angiotensin II receptors → decreases vasoconstriction, sodium retention, and cardiac strain.
Together, these mechanisms improve survival and heart function in HFrEF patients.
Safety advice
| ACE inhibitor interaction | Never take concurrently. Maintain a 36-hour gap between stopping ACE inhibitors and starting Arnicor. |
| Kidney function | Regular monitoring of creatinine and potassium is required. |
| Low BP | Risk is highest during the first weeks — stand up slowly and report fainting. |
| Pregnancy | Contraindicated — may cause fetal harm. |
| Liver impairment | Use cautiously; dose adjustments may be needed. |
| Drug interactions | Caution with potassium-sparing diuretics, NSAIDs, lithium, and high-dose diuretics. |
What if you forget a dose?
- Take it as soon as you remember.
- If it’s near the next dose, skip the missed dose.
- Do NOT double the dose.
All substitutes
- Entresto (reference brand)
- ACE inhibitors (enalapril, ramipril) — but not taken together
- ARBs (valsartan, losartan)
- Comprehensive heart-failure therapies (beta-blocker, MRA, SGLT2 inhibitor)
Quick tips
- Check BP daily at home — keep a log for clinic visits.
- Report swelling of face or throat immediately.
- Avoid potassium salt substitutes.
- Do not stop abruptly — worsening heart failure can occur.
- Take consistently twice daily for best effect.
Fact Box
| Generic name | Sacubitril/Valsartan |
| Brand | Arnicor 100 mg |
| Drug class | ARNI (Angiotensin Receptor–Neprilysin Inhibitor) |
| Form | Oral tablet (100 mg) |
| Typical dose | 50 mg → 100 mg → 200 mg BID titration |
| Prescription | Required — cardiology supervision recommended |
Patient concerns
Does Arnicor cure heart failure? No — but it significantly improves survival and reduces hospitalisation when used long term.
How fast does it work? Symptom improvement may start in days; long-term benefits occur over months.
User feedback
Patients report improvements in breathlessness and swelling. Some experience dizziness from low BP, especially early on. Potassium and kidney monitoring help manage side effects.
FAQs
Can I take Arnicor with an ACE inhibitor?
No. A 36-hour washout is mandatory to avoid angioedema risk.
Is it safe in kidney disease?
Use with caution; dose adjustment and close monitoring are essential.
How should I store Arnicor?
Store at room temperature, away from moisture and heat.
Related products
- Entresto
- Valsartan
- Enalapril / Ramipril
- SGLT2 inhibitors (empagliflozin, dapagliflozin)
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Disclaimer:
This content is for educational use only and not a substitute for medical advice. Arnicor (sacubitril/valsartan) must be prescribed and monitored by a qualified clinician.
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Lab tests offered by us
- Kidney function (creatinine, eGFR)
- Potassium levels
- Blood pressure monitoring
- BNP / NT-proBNP (heart-failure markers)
Additional offers
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