Nebicard-V (Nebivolol 5 mg / Valsartan 80 mg)
Nebicard-V (Nebivolol 5 mg / Valsartan 80 mg) is a fixed-dose combination tablet pairing nebivolol — a selective β1-blocker with nitric-oxide–mediated vasodilatory activity — with valsartan, an angiotensin-II receptor blocker (ARB). Together they provide complementary mechanisms for effective blood-pressure reduction and cardiovascular protection.
The combination simplifies therapy when a β-blocker plus ARB strategy is appropriate and may improve adherence versus separate tablets. Prescriber supervision is required to individualise dosing and monitor safety.
Product introduction
Nebivolol lowers heart rate and reduces cardiac output while enhancing endothelial nitric oxide release to promote vasodilation. Valsartan blocks angiotensin II type-1 receptors, decreasing vasoconstriction, aldosterone release and sodium retention. The combined effect reduces systemic vascular resistance and blood pressure through complementary vascular and neurohormonal pathways.
Uses of Nebicard-V (Nebivolol/Valsartan)
Typical clinical indications include:
- Essential hypertension requiring combination therapy
- Patients uncontrolled on monotherapy with nebivolol or valsartan
- When a β-blocker + ARB approach is selected by the treating clinician
Note: Use is guided by prescriber assessment of comorbidities, heart rate, renal function and patient preferences.
Benefits of Nebicard-V
- Complementary mechanisms: rate control + vasodilation + RAAS blockade for robust BP lowering.
- Once-daily convenience: fixed combination may increase adherence.
- Potential metabolic advantages: nebivolol’s nitric-oxide effect may be neutral or favourable for metabolic parameters compared with older non-selective beta-blockers.
- Reduced pill burden: useful for patients on multiple medications.
Recommended dosing
Usual prescriber guidance (individualise according to clinical context):
- Standard dose: one tablet once daily (nebivolol 5 mg / valsartan 80 mg).
- Take at the same time each day, with or without food.
- Do not split, crush or chew the tablet unless your pharmacist advises otherwise.
- Prescribers may prefer to start with individual agents or lower doses in frail patients, the elderly, or those with low baseline blood pressure, then switch to the fixed combination once tolerated.
Side effects of Nebicard-V
Adverse effects reflect contributions from both nebivolol and valsartan.
Common side effects
- Dizziness or lightheadedness (especially after initiation)
- Fatigue
- Headache
- Bradycardia (slow heart rate)
- Occasional cough (less common than with ACE inhibitors)
- Minor electrolyte changes or increased urination (less likely at this valsartan dose but monitor)
Important risks: symptomatic hypotension, marked bradycardia, worsening heart failure in some cases, kidney function changes, hyperkalaemia (particularly if combined with potassium supplements or potassium-sparing diuretics), and rare allergic reactions. Seek urgent care for fainting, severe dizziness, chest pain, swelling of face/throat, sudden breathlessness, or signs of severe electrolyte imbalance (muscle weakness, irregular heartbeat).
How to use Nebicard-V
- Take exactly as prescribed — one tablet once daily is typical.
- Measure and record home blood pressures during initiation and after dose adjustments; report symptomatic low BP or slow pulse to your clinician.
- Maintain adequate hydration; thiazide or high-dose diuretics used concurrently may increase hypotension risk.
- Do not stop beta-blocker therapy abruptly — taper under medical supervision if discontinuation is required.
- If vomiting or inability to take oral meds occurs, contact your prescriber; temporary adjustments may be needed.
How Nebicard-V works
Nebivolol selectively blocks cardiac β1 receptors reducing heart rate and myocardial oxygen demand while enhancing nitric oxide–mediated vasodilation. Valsartan antagonises angiotensin II receptors, decreasing vasoconstriction and aldosterone-mediated volume retention. Together they lower blood pressure via decreased cardiac output and reduced systemic vascular resistance with neurohormonal modulation.
Safety advice
| Pregnancy | Valsartan (an ARB) is contraindicated in pregnancy — avoid use in women planning pregnancy. Women of childbearing potential should discuss contraception and pregnancy plans with their clinician. |
| Breastfeeding | Discuss risks/benefits with your prescriber — components may pass into breastmilk and use should be considered carefully. |
| Asthma / COPD | Although nebivolol is β1-selective, caution is recommended in patients with reactive airways disease — discuss risks with your clinician. |
| Diabetes | Beta-blockers may mask some symptoms of hypoglycaemia (tachycardia). Monitor glucose closely and inform your diabetes team of therapy changes. |
| Kidney function & electrolytes | Monitor serum creatinine and potassium periodically — ARBs can increase potassium and affect renal function, especially when combined with other RAAS agents or potassium-sparing drugs. |
| Drug interactions | Use caution with other antihypertensives, antiarrhythmics, potassium supplements, NSAIDs (which can blunt ARB effect), and CYP2D6 inhibitors (may affect nebivolol levels). Provide a full medicines list to your prescriber and pharmacist. |
What if you forget a dose?
- Take the missed dose as soon as you remember the same day.
- If it is near the time for the next dose, skip the missed dose — do not double up.
- If you miss several doses or are unsure, contact your prescriber for guidance.
All substitutes
Equivalent therapeutic strategies chosen by prescribers may include:
- Separate nebivolol and valsartan tablets to allow individual dose titration
- Other β-blocker + ARB combinations (e.g., bisoprolol + losartan) depending on comorbidities
- Alternative combination antihypertensives: ACE inhibitor + diuretic, CCB + ARB, or ARB + thiazide
Quick tips
- Take at the same time each day for consistent blood levels.
- Check blood pressure and pulse regularly during the first weeks of therapy.
- Avoid sudden posture changes to reduce dizziness (rise slowly).
- Limit alcohol — it may worsen hypotension and dizziness.
- Do not use potassium supplements or potassium-sparing diuretics without clinician approval.
Fact Box
| Generic names | Nebivolol / Valsartan |
| Brand | Nebicard-V (Nebivolol 5 mg / Valsartan 80 mg) |
| Drug class | β1-selective beta-blocker (vasodilating) + ARB |
| Form | Oral tablet (fixed-dose combination) |
| Typical dose | One tablet once daily (or as prescribed) |
| Prescription | Required — prescriber supervision and periodic monitoring |
Patient concerns
Will Nebicard-V lower my blood pressure right away? Some reduction may be seen within hours–days, but full effect is assessed over weeks. Continue therapy and attend follow-up for dose optimisation.
Can I stop it if I feel dizzy? Do not stop abruptly. If dizziness is troublesome, contact your prescriber — they may adjust the dose or timing.
User feedback
Many patients appreciate the convenience of once-daily combination therapy and report good blood-pressure control. Some experience initial fatigue, lightheadedness or slow pulse which commonly improves after dose adjustment.
FAQs
Can Nebicard-V be used in pregnancy?
No — valsartan (an ARB) is contraindicated in pregnancy. Women of childbearing potential should discuss contraception and pregnancy plans with their clinician.
Do I need blood tests on Nebicard-V?
Your clinician may check kidney function and potassium after initiation or dose changes and periodically during long-term therapy.
How should I store Nebicard-V?
Store at room temperature away from moisture and heat. Keep out of reach of children and do not use past the expiry date.
Related products
- Nebivolol 5 mg (monotherapy)
- Valsartan 80 mg (monotherapy)
- Other combination antihypertensives (ARB/HCTZ, ACEi/CCB, etc.)
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Disclaimer:
This article is for educational purposes only and does not replace personalised medical advice. Nebicard-V (nebivolol/valsartan) must be prescribed and monitored by a qualified clinician. Do not change or stop therapy without consulting your healthcare provider.
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For order or prescription verification use live chat or our contact page. For medical emergencies (severe dizziness, fainting, chest pain, severe shortness of breath) seek urgent care immediately.
Lab tests
- Blood pressure monitoring
- Serum creatinine & eGFR
- Serum potassium
- ECG / heart-rate evaluation if indicated
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Prescription coordination and adherence support available on request. Use code GLOBAL10 where eligible for first-order discounts.
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