Buy Arnicor 200 mg (Sacubitril / Valsartan) – Proven ARNI Therapy for Heart Failure

Arnicor 200 mg is a combination of sacubitril (about 97 mg) and valsartan (about 103 mg) by Cipla. It belongs to the class called angiotensin receptor–neprilysin inhibitors (ARNI) and is indicated for chronic heart failure with reduced ejection fraction (HFrEF) to reduce mortality and hospitalization risk. 

How It Works

Sacubitril increases levels of beneficial peptides by inhibiting neprilysin, promoting vasodilation and sodium excretion. Valsartan blocks angiotensin II receptors, reducing vasoconstriction and fluid retention. Together, they improve heart failure outcomes. 

Indications & Benefits

• FDA-approved for adults with chronic HFrEF (NYHA Class II–IV) based on PARADIGM-HF trial.
• Recommended guideline therapy to replace ACE inhibitors or ARBs when tolerated. 
• Shown to reduce cardiovascular death and hospitalization rates in HFrEF patients. 

Dosage & Titration

• Standard titration: Start with 49/51 mg twice daily, double to 97/103 mg BID after 2–4 weeks if tolerated.
• Arnicor 200 mg corresponds to ~97 mg sacubitril + 103 mg valsartan—the target dose given twice daily.
• Do not initiate within 36 hours of an ACE inhibitor to reduce angioedema risk. 

Side Effects & Safety

• Common: hypotension, hyperkalemia, renal dysfunction, dizziness. Cough is less common than with ACE inhibitors.
• Rare but serious: angioedema—especially in patients with prior ACE inhibitor–related reactions.
• Contraindications: pregnancy (valsartan is teratogenic), history of angioedema, severe liver or kidney impairment.

Precautions & Drug Interactions

• Observe 36-hour washout when switching from ACE inhibitors to sacubitril/valsartan to avoid angioedema. Coadministration is contraindicated. 
• Monitor electrolytes and renal function regularly—particularly blood potassium and creatinine.
• Avoid potassium‐sparing diuretics, NSAIDs, and aldosterone antagonists without monitoring—risk of hyperkalemia and renal impairment.

Global Availability & Prescription Info

Arnicor 200 mg is prescription-only and manufactured by Cipla. It’s available globally via licensed pharmacies, with discreet, tracked shipping. Use under medical supervision, typically alongside beta-blockers or aldosterone antagonists.

📌 Frequently Asked Questions (FAQs)

1. What’s Arnicor 200 mg used for?

It treats chronic heart failure with reduced ejection fraction (HFrEF) to lower risk of hospitalization and cardiovascular death. Used in NYHA II–IV patients not well managed by ACE inhibitors/ARBs.

2. What dose should I take?

Start at 49/51 mg BID, then increase to 97/103 mg BID (~Arnicor 200 mg total) after 2–4 weeks as tolerated. Keep at least 36 hours gap from any ACE inhibitor use. 

3. What side effects may occur?

Mild symptoms like dizziness, low blood pressure, elevated potassium, or kidney function changes are possible. Rare angioedema cases have occurred—stop immediately if swelling occurs.

4. Can I take it with other medications?

Not with ACE inhibitors. Be cautious with potassium-altering drugs, NSAIDs, and diuretics. Monitor labs regularly.

5. Who should avoid Arnicor?

Pregnant women, those with prior ACE-inhibitor angioedema, severe renal/hepatic impairment, or low blood pressure should avoid this medication. Use only under physician supervision.