CA Atra 10 mg (All-trans Retinoic Acid)
CA Atra 10 mg contains all-trans retinoic acid (ATRA), a vitamin A–derived differentiating agent used in the treatment of acute promyelocytic leukemia (APL). ATRA induces differentiation of leukemic promyelocytes and, when combined with anthracycline chemotherapy or arsenic trioxide per oncologist protocol, can produce high remission rates in APL.
ATRA is a specialised oncology medicine and must be prescribed and supervised by a haematologist/oncologist with careful monitoring for known risks such as differentiation syndrome and liver toxicity.
Product introduction
All-trans retinoic acid (tretinoin) is a targeted therapy for APL (usually in patients with the PML-RARα fusion). CA Atra 10 mg tablets provide an oral formulation for daily dosing as part of induction, consolidation or maintenance protocols, depending on the treating physician’s plan. Treatment should be delivered in an oncology setting with access to supportive care and laboratory monitoring.
This medicine is prescription-only and is not appropriate for non-oncology uses.
Uses of CA Atra 10 mg (All-trans Retinoic Acid)
CA Atra 10 mg is indicated for:
- Treatment of acute promyelocytic leukemia (APL) as part of induction and consolidation therapy
- Combination therapy with chemotherapy (anthracyclines) or arsenic trioxide according to established protocols
- Maintenance therapy in selected patients as directed by an oncologist
Note: Use is restricted to confirmed APL under haematologist supervision. Not for cosmetic or dermatologic use despite being a retinoid derivative.
Benefits of CA Atra 10 mg (All-trans Retinoic Acid)
Clinical benefits include:
- Induces differentiation of malignant promyelocytes, restoring maturation pathways
- High remission rates when used with appropriate combination therapy
- Oral formulation convenient for inpatient and outpatient components of therapy
- Established role in modern APL treatment algorithms with curative potential
In Treatment of Worm infections
Important: CA Atra is not an antiparasitic agent and does not treat worm infections. This heading is included to match your standard page layout.
Side effects of CA Atra 10 mg
ATRA has a distinct toxicity profile. Many side effects are manageable with monitoring and supportive care—but some are serious or life-threatening.
Common side effects
- Headache
- Fever
- Dry skin, cheilitis (chapped lips)
- Elevated serum triglycerides
- Mild elevations in liver enzymes
- Nausea, vomiting
Serious but potentially life-threatening: differentiation syndrome (formerly retinoic acid syndrome) — presents with fever, weight gain, respiratory distress, pulmonary infiltrates, hypotension and organ dysfunction; requires immediate corticosteroid therapy and possible temporary discontinuation of ATRA. Severe hepatotoxicity, severe skin reactions and intracranial hypertension have also been reported. Prompt recognition and specialist management are essential.
How to use CA Atra 10 mg (All-trans Retinoic Acid)
- Take exactly as prescribed by your treating oncologist—do not self-adjust dose.
- Typical adult dosing regimens vary (often 45 mg/m²/day divided into two doses) — CA Atra 10 mg tablets are one formulation; oncologists calculate total daily dose and tablet count.
- Swallow tablets whole with water; do not crush.
- Maintain consistent timing with meals if advised by your clinician to optimise tolerability.
- Do not stop treatment suddenly without consulting your oncology team—exceptions apply if severe toxicity occurs and specialist advice directs temporary interruption.
Patients receiving ATRA routinely require hospital access during induction for intensive monitoring and supportive therapy.
How CA Atra 10 mg (All-trans Retinoic Acid) works
All-trans retinoic acid binds to the PML-RARα oncoprotein and alters transcriptional repression, releasing the block on promyelocyte differentiation. This biochemical effect enables leukemic promyelocytes to mature into non-proliferative cells, reducing leukemic burden when combined with appropriate cytotoxic or targeted therapies.
Safety advice
| Specialist supervision | Only use under a haematologist/oncologist with facility for immediate intervention. |
| Monitoring | Frequent clinical review, daily blood counts during induction, liver function tests, lipids and fluid balance monitoring are required. |
| Differentiation syndrome | Early recognition is critical — treat promptly with high-dose corticosteroids and supportive care; temporary ATRA interruption may be needed. |
| Pregnancy | Highly teratogenic—not to be used in pregnancy. Women of childbearing potential must use effective contraception and confirm negative pregnancy tests before and during therapy. |
| Breastfeeding | Do not breastfeed during treatment and until cleared by specialist. |
| Drug interactions | Multiple interactions possible via hepatic metabolism—inform your oncology team about all concomitant medications, herbal supplements, and OTC products. |
What if you forget to take CA Atra 10 mg?
If you miss a dose, follow the instructions provided by your oncology team. In many regimens, take the missed dose as soon as possible unless it is close to the next scheduled dose—confirm with your specialist. Do not double doses without medical advice.
All substitutes
Substitution and alternative regimens are determined by the treating oncologist and local protocols; possible alternatives or complementary agents in APL management include:
- Arsenic trioxide (ATO) — used in combination or as an alternative in certain protocols
- Differing ATRA brands or generics (tretinoin formulations)
- Anthracycline chemotherapy (e.g., daunorubicin) as part of combination regimens
Any substitution must be guided by oncology specialists and local treatment guidelines.
Quick tips
- Always carry details of your diagnosis and treatment plan (e.g., a patient card) when traveling.
- Report fever, sudden breathlessness, rapid weight gain, or chest pain immediately.
- Maintain scheduled blood tests and clinic visits—these are essential for safe therapy.
- Avoid pregnancy during and for an advised period after treatment; discuss contraception with your oncologist.
Fact Box
| Generic name | All-trans retinoic acid (Tretinoin / ATRA) |
| Brand | CA Atra 10 mg |
| Drug class | Retinoid / Differentiating agent (oncology) |
| Form | Oral tablet (10 mg) |
| Use | Acute promyelocytic leukemia (APL) — specialist oncology therapy |
| Prescription | Required — oncology/haematology only |
Patient concerns
Will CA Atra cure my APL? When used appropriately in modern protocols (ATRA + arsenic trioxide or ATRA + chemotherapy), APL has high remission and cure rates; outcomes depend on multiple clinical factors—discuss prognosis with your oncologist.
How quickly will I respond? Haematologic responses are often seen within days to weeks, but full remission assessment and consolidation require structured protocols and monitoring.
User feedback
Patients treated for APL with ATRA-based regimens commonly report intensive monitoring during induction but favourable long-term outcomes when treatment and follow-up are adhered to. Side effects such as skin dryness and mouth soreness are frequent; differentiation syndrome is rare but serious.
Are you currently on CA Atra 10 mg? Please share your experience with your care team — any patient-reported outcomes should be discussed with your specialist.
FAQs
Can women take CA Atra?
No—ATRA is highly teratogenic. Women of reproductive potential must not take ATRA unless pregnancy is excluded and effective contraception is used; discuss with your oncologist.
What is differentiation syndrome and how is it treated?
Differentiation syndrome is a potentially life-threatening inflammatory response characterised by fever, respiratory distress, fluid retention and organ dysfunction. Immediate treatment with high-dose corticosteroids (e.g., dexamethasone) and supportive care is required; temporary ATRA interruption may be necessary—this must be managed in hospital by specialists.
Can CA Atra be used with other cancer drugs?
Yes — ATRA is commonly combined with anthracyclines or arsenic trioxide in APL regimens. Combination therapy is determined by the treating team and protocol.
How should I store CA Atra?
Store at room temperature, protected from light and moisture. Keep out of reach of children and do not use past expiry date.
Related products
- View oncology medicines & supportive care
- Arsenic trioxide (ATO) — specialist supply
- Supportive medicines (antiemetics, corticosteroids) — clinician prescribed
Want to share the information?
Share this page with patients and caregivers to support informed, safe oncology care. Always reinforce that specialist supervision is essential.
Disclaimer:
This article is for educational purposes and does not replace specialist medical advice. CA Atra 10 mg (all-trans retinoic acid) is an oncology medication that must be prescribed and monitored by qualified haematology/oncology teams. Do not self-medicate.
References
- Contemporary APL treatment guidelines and specialist oncology literature
- Pharmacology references for all-trans retinoic acid (tretinoin)
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- Full blood count (daily during induction as required)
- Liver function tests (LFTs)
- Serum triglycerides and renal profile
- Coagulation profile (when clinically indicated)
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