Calutide 50 mg (Bicalutamide)
Calutide 50 mg contains bicalutamide, a non-steroidal antiandrogen used as part of androgen-deprivation strategies in prostate cancer. Bicalutamide blocks androgen receptors on prostate cancer cells, reducing androgen-driven tumour growth. Common use is in combination with LHRH (GnRH) analogues as part of combined androgen blockade. :contentReference[oaicite:1]{index=1}
Calutide is a prescription oncology medicine; initiation and continuation require specialist urology/oncology oversight and scheduled monitoring.
Product introduction
Bicalutamide (50 mg) is widely used in adult men with prostate cancer, typically given once daily. It may be prescribed as monotherapy in special settings or more commonly together with LHRH analogues (goserelin, leuprolide) to block androgen production and androgen receptor activity. :contentReference[oaicite:2]{index=2}
Uses of Calutide 50 mg (Bicalutamide)
Common indications include:
- Advanced or metastatic prostate cancer as part of combined androgen blockade
- Locally advanced prostate cancer in selected schedules
- Used in some adjuvant or neoadjuvant protocols per specialist decision
Note: Treatment choice, timing and duration depend on disease stage, comorbidities and physician judgement. Always follow your treating clinician’s plan. :contentReference[oaicite:3]{index=3}
Benefits of Calutide 50 mg (Bicalutamide)
Why bicalutamide is used:
- Androgen receptor blockade: reduces tumour stimulation by androgens.
- Oral once-daily dosing: convenient administration for outpatient care.
- Proven clinical role: used in combination with LHRH analogues for disease control in men with advanced prostate cancer. :contentReference[oaicite:4]{index=4}
In Non-Oncology Conditions
Important: Bicalutamide is an antiandrogen for prostate disease and is not suitable for routine non-oncology uses unless prescribed by a specialist (for example, some off-label uses in selected transgender care or severe hirsutism are specialty-managed). This heading is included to preserve page structure.
Side effects of Calutide 50 mg (Bicalutamide)
Bicalutamide has well-documented adverse effects. Most are manageable but some require prompt evaluation.
Common side effects
- Hot flashes
- Gynecomastia and breast pain/tenderness
- Fatigue, weakness
- Decreased libido and sexual dysfunction
- Gastrointestinal upset (nausea)
- Transient liver enzyme elevations — monitor LFTs
Serious but uncommon risks: clinically significant hepatotoxicity (rare but reported), interstitial lung disease (rare), and rare severe allergic reactions. Report jaundice, dark urine, severe abdominal pain, unexplained breathlessness or new persistent cough immediately. :contentReference[oaicite:5]{index=5}
How to use Calutide 50 mg (Bicalutamide)
- Typical adult dose: 50 mg once daily, taken at the same time each day (morning or evening) as prescribed by your clinician. :contentReference[oaicite:6]{index=6}
- Swallow tablets whole with water; do not crush unless instructed by your pharmacist.
- When given with an LHRH analogue, bicalutamide is usually started at least a few days before or at the same time as the LHRH agent to reduce the risk of testosterone flare in some protocols. :contentReference[oaicite:7]{index=7}
- Attend scheduled monitoring visits (CBC, LFTs, clinical review) and report side effects promptly.
- Do not stop therapy without discussing with your treating team; supervised dose changes or interruptions may be required for toxicity.
How Calutide works
Bicalutamide competitively inhibits androgen receptors in prostate tissue, preventing testosterone and dihydrotestosterone (DHT) from stimulating tumour growth. When used with LHRH analogues, it helps blunt androgen receptor signalling while systemic androgen levels are reduced. :contentReference[oaicite:8]{index=8}
Safety advice
| Pregnancy / Women | Not indicated for women of childbearing potential without specialist oversight — antiandrogens may have serious effects on a female fetus. Bicalutamide is primarily prescribed for men with prostate cancer. |
| Breastfeeding | Not applicable / not indicated in breastfeeding women for prostate cancer; avoid unless specialist advises otherwise. |
| Liver monitoring | Hepatic enzyme elevations have been reported — LFTs should be checked before starting and periodically during treatment. Discontinue if clinically significant hepatotoxicity occurs. :contentReference[oaicite:9]{index=9} |
| Cardiac / Pulmonary | Report chest pain, palpitations, breathlessness, or persistent cough immediately — rare pulmonary reactions have been reported. :contentReference[oaicite:10]{index=10} |
| Drug interactions | Bicalutamide is metabolised in the liver and may interact with other medicines metabolised by CYP pathways; it has been reported to have weak inhibitory effects on CYP3A4 and may affect drugs like certain anticoagulants. Always provide a full medication list to your oncology pharmacist. :contentReference[oaicite:11]{index=11} |
| Vaccination | Discuss vaccines with your clinician; no routine live vaccine guidance specific to bicalutamide but follow general oncology/vaccination recommendations. |
What if you forget to take Calutide?
- If you miss a dose, take it as soon as you remember on the same day unless it is almost time for the next dose.
- Do not double the next dose to make up for a missed one.
- If several doses are missed, contact your treating clinician for advice on how to resume safely.
All substitutes
Alternative antiandrogens and treatment options are chosen by specialists depending on disease context. Examples include:
- Other non-steroidal antiandrogens (specialist selected)
- Chemotherapy or novel hormonal agents for castration-resistant disease
- Combination regimens with LHRH analogues or surgical castration
Any substitution must be directed by the treating urologist/oncologist.
Quick tips
- Take at the same time daily for consistent blood levels.
- Report breast swelling, tenderness, new jaundice, or breathlessness promptly.
- Keep all scheduled blood tests to monitor liver and blood parameters.
- Carry a treatment card listing Calutide and emergency contacts.
Fact Box
| Generic name | Bicalutamide |
| Brand | Calutide 50 mg |
| Drug class | Non-steroidal antiandrogen |
| Form | Oral tablet (50 mg) |
| Typical regimen | 50 mg once daily (with or without LHRH analogues as directed) |
| Prescription | Required — urology/oncology specialist |
Patient concerns
Will Calutide cure my prostate cancer? Response and long-term outcome depend on disease stage, biology and combined treatments. Bicalutamide is one tool among many; discuss prognosis and goals of care with your treating team.
How quickly do side effects appear? Hot flashes and breast tenderness/gynecomastia often appear within weeks; liver enzyme changes can occur within the first months — monitor and report symptoms early. :contentReference[oaicite:12]{index=12}
User feedback
Many patients value the convenience of once-daily oral therapy; common complaints include hot flashes, fatigue and breast tenderness. Most side effects are managed with supportive measures or dose changes under specialist guidance.
Are you currently taking Calutide 50 mg? Let us know how it is working for you by taking this survey.
FAQs
Can I stop Calutide when side effects occur?
Do not stop without speaking to your treating clinician. Some side effects can be managed by dose interruption or supportive care; your specialist will advise the safest approach.
Is Calutide safe if I have kidney disease?
Bicalutamide pharmacokinetics are not significantly altered by mild renal impairment, but always inform your clinician about kidney disease so dosing and monitoring can be individualized. :contentReference[oaicite:13]{index=13}
Can Calutide interact with warfarin or other anticoagulants?
Interactions with coumarin anticoagulants (e.g., warfarin) and other medicines have been reported — more frequent INR monitoring may be required if co-prescribed. Discuss all medicines and supplements with your healthcare team. :contentReference[oaicite:14]{index=14}
How should I store Calutide?
Store at room temperature away from moisture and heat. Keep out of reach of children and do not use after the expiry date.
Related products
- LHRH (GnRH) analogues used in combined androgen blockade
- Other systemic prostate cancer therapies
- View all urology & oncology medicines
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Disclaimer:
This article is for educational purposes only and does not replace specialist medical advice. Calutide (bicalutamide) must be prescribed and monitored by qualified clinicians. Do not self-medicate.
References
- Mayo Clinic / patient & prescribing information for bicalutamide (typical dosing 50 mg once daily). :contentReference[oaicite:15]{index=15}
- Drug information summaries and dosing guidance (Drugs.com / prescribing references). :contentReference[oaicite:16]{index=16}
- Regulatory product information and safety warnings (FDA label / product monographs). :contentReference[oaicite:17]{index=17}
- Case reports and reviews on hepatotoxicity and serious adverse events. :contentReference[oaicite:18]{index=18}
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