Celkeran 2 mg (Chlorambucil)
Celkeran 2 mg contains chlorambucil, an oral alkylating chemotherapy agent from the nitrogen mustard family. Chlorambucil is commonly used in haematology for the management of chronic lymphocytic leukaemia (CLL), certain indolent non-Hodgkin lymphomas, and selected palliative situations. It works by forming cross-links in DNA, interfering with DNA replication and causing cell death in rapidly dividing malignant cells.
Celkeran 2 mg is a prescription cytotoxic medicine and must be used under the care of a haematologist/oncologist with regular blood monitoring and clinical follow-up.
Product introduction
Chlorambucil is a well-established oral alkylator with decades of clinical experience. The 2 mg tablet strength provides dosing flexibility for tailored regimens — from low-dose continuous approaches to intermittent pulse schedules. It remains useful for outpatient treatment, particularly in older or frail patients who may not tolerate intensive intravenous chemotherapy.
Modern haematology practice increasingly uses targeted agents for many indications, but chlorambucil retains a role where oral, low-toxicity control is appropriate or when other options are contraindicated.
Uses of Celkeran 2 mg (Chlorambucil)
Clinical uses commonly include:
- Chronic lymphocytic leukaemia (CLL) — as first-line therapy in some older or frail patients or for disease control
- Indolent non-Hodgkin lymphomas (e.g., follicular lymphoma) — palliative or maintenance approaches
- Selected autoimmune haematologic conditions in specialist programmes (off-label, clinician-directed)
- Occasional inclusion in combination regimens directed by the treating haematologist
Note: Precise indications and preferred agents vary by region, clinical guidelines and patient factors. Always follow your treating specialist’s recommendations.
Benefits of Celkeran 2 mg (Chlorambucil)
Key benefits include:
- Oral dosing permits outpatient therapy and easier administration for long-term disease control.
- Flexible dosing with 2 mg tablets allows precise titration according to weight, blood counts, and tolerability.
- Generally well tolerated acutely compared to aggressive IV regimens—suitable for older or comorbid patients.
- Cost-effective option in many healthcare settings.
In Treatment of Worm infections
Important: Chlorambucil does not treat parasitic or worm infections. This section is present only to preserve your page’s required structure.
Side effects of Celkeran 2 mg (Chlorambucil)
Adverse effects are largely related to bone marrow suppression and the alkylating mechanism of the drug. Most side effects are manageable with appropriate monitoring and dose adjustments, but some can be severe or long-term.
Common side effects
- Neutropenia, thrombocytopenia, anaemia (low blood counts)
- Nausea, vomiting
- Loss of appetite, weight loss
- Fatigue and malaise
- Mouth soreness or stomatitis
- Skin rash and increased photosensitivity
Serious and long-term risks: profound bone marrow suppression with infection or bleeding risk, prolonged cytopenias, infertility in both sexes, risk of secondary malignancies (therapy-related myelodysplastic syndrome or acute myeloid leukaemia), and rare hepatic or renal toxicity. Seek immediate medical care for fever, unexplained bruising/bleeding, severe fatigue or symptoms suggesting infection.
How to use Celkeran 2 mg (Chlorambucil)
- Take chlorambucil exactly as prescribed by your haematologist.
- Dosing schedules vary considerably — typical approaches include low-dose daily administration (e.g., 2–6 mg daily depending on body size and protocol) or intermittent pulse dosing (e.g., several days on followed by a rest period). Your specialist will provide a regimen customised to your condition.
- Swallow tablets whole with water; do not crush unless your pharmacist advises an alternative formulation.
- Take at the same time each day to maintain consistent exposure.
- Do not alter or stop treatment without consulting your treating team — dose modifications are common when blood counts or side effects occur.
Frequent blood tests (CBC), liver and renal function assessments are essential before and during treatment to guide dosing and detect toxicity early.
How Celkeran 2 mg (Chlorambucil) works
Chlorambucil alkylates DNA by introducing alkyl groups that form cross-links between DNA strands. These cross-links prevent separation of DNA during replication and transcription, leading to cell-cycle arrest and apoptosis. Rapidly dividing malignant lymphocytes are particularly susceptible, which explains chlorambucil’s activity in CLL and indolent lymphomas.
Safety advice
| Pregnancy | Contraindicated. Chlorambucil is teratogenic and may cause fetal harm. Women of childbearing potential must use effective contraception and avoid pregnancy during and for a recommended period after therapy. |
| Breastfeeding | Not recommended — cytotoxic drugs can be excreted in breast milk and may harm the infant. |
| Fertility | May cause infertility in men and women. Discuss fertility preservation options before starting treatment. |
| Infections | Neutropenia increases infection risk — contact your healthcare team immediately for fever or signs of infection. |
| Vaccination | Avoid live vaccines during and for a period after cytotoxic therapy; inactivated vaccines should be discussed with your clinician regarding timing and expected response. |
| Drug interactions | Chlorambucil may interact with medicines that affect bone marrow (e.g., warfarin, allopurinol, other cytotoxics). Provide a full list of all prescription, OTC and herbal medicines to your treating team. |
| Liver & kidney disease | Dose adjustments may be needed for organ impairment; regular monitoring of LFTs and renal function is advised. |
What if you forget to take Celkeran 2 mg?
If you miss a dose:
- Follow the specific instructions provided by your clinic or haematology nurse — regimens differ.
- Generally, if you remember on the same day take the missed dose; if it is too close to the next scheduled dose, skip the missed dose.
- Do not double the dose to make up for missed tablets.
- Inform your treating team if multiple doses are missed — they may need to adjust the cycle or monitoring schedule.
All substitutes
Alternative therapies are chosen based on diagnosis, prognostic markers and patient fitness. Options include:
- Targeted agents such as ibrutinib, acalabrutinib, or venetoclax (in CLL where appropriate)
- Other cytotoxic agents such as fludarabine or bendamustine in certain regimens
- Cyclophosphamide-based approaches in selected protocols
Choice of substitute requires discussion with a haematologist and is influenced by molecular testing, comorbidities and treatment goals.
Quick tips
- Carry a treatment card listing medications, oncology contact details and emergency instructions.
- Avoid crowded places and people with active infections during periods of low white cell counts.
- Report fever (≥38°C), unusual bruising, bleeding, severe cough or difficulty breathing immediately.
- Use contraception during therapy and for the period recommended by your specialist after finishing treatment.
- Store tablets as instructed — keep out of reach of children.
Fact Box
| Generic name | Chlorambucil |
| Brand | Celkeran 2 mg |
| Drug class | Alkylating agent (nitrogen mustard analogue) |
| Form | Oral tablet (2 mg) |
| Typical use | Chronic lymphocytic leukaemia (CLL), indolent lymphomas — specialist-directed |
| Prescription | Required — haematology/oncology specialist |
Patient concerns
Will Celkeran cure my disease? Chlorambucil is used to control disease and relieve symptoms in many indolent haematologic conditions; cure depends on disease type, stage and available modern therapies. Many patients achieve prolonged disease control, but treatment goals should be discussed with your specialist.
How will I be monitored? Expect regular blood tests (CBC), liver and kidney function tests, and clinic reviews to detect cytopenias and organ toxicity early — monitoring frequency is determined by your treating team.
User feedback
Patients and caregivers often value oral administration and outpatient convenience. Common patient-reported issues include fatigue, nausea and susceptibility to infections during periods of low white blood cells. Long-term considerations such as effects on fertility and secondary malignancy risk are typically discussed before starting therapy.
Are you currently taking Celkeran 2 mg (Chlorambucil)? Share any concerns with your haematology team — do not stop medication without professional advice.
FAQs
Can I take Celkeran with other medicines?
Only under specialist instruction. Many medicines interact with cytotoxic therapy; always inform your haematology team about prescription, OTC and herbal products.
Do I need fertility counselling before starting chlorambucil?
Yes. Chlorambucil can impair fertility — discuss sperm or egg preservation options prior to treatment if relevant.
How long will treatment last?
Duration varies by protocol — treatment may be intermittent or continuous depending on disease control, tolerability and treatment goals. Your haematologist will advise the expected course.
How should I store Celkeran?
Store at room temperature away from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date.
Related products
- Fludarabine — alternative in certain CLL regimens
- Bendamustine — used for indolent lymphoma and some CLL cases
- Targeted agents — e.g., ibrutinib, venetoclax (specialist-directed)
- View all oncology medicines
Want to share the information?
Share this page to help others understand chlorambucil therapy and safe use.
Disclaimer:
This article is for educational purposes only and does not replace specialist haematology/oncology advice. Celkeran (chlorambucil) must be prescribed and monitored by qualified clinicians. Do not self-medicate.
References
- Haematology and oncology clinical guidelines
- Pharmacology and safety literature for alkylating agents
- National treatment protocols for CLL and indolent lymphomas
Marketer details
genericurerx — support@genericurerx.com — www.genericurerx.com
In case of any issues, contact us
For order support use live chat or our contact page. Medical concerns should be directed to your haematology/oncology team immediately.
Lab tests offered by us
- Complete Blood Count (CBC) with differential
- Liver Function Tests (LFTs)
- Renal profile
- Fertility preservation counselling referral
- Infection screening where clinically indicated
Additional offers
Patient support services, treatment coordination and prescription verification available on request. Use code GLOBAL10 where eligible for first-order discounts.
What are you using this medicine for?
Select at checkout so our pharmacy team can provide personalised counselling and support.
Know Us
Specialist haematology & oncology pharmacy with global delivery and clinical support services.
Our Policies
Prescription verification • Secure packaging • Patient privacy protected
Our Services
Worldwide shipping • Oncology pharmacist support • Lab test coordination
Connect
Follow us for oncology treatment updates and patient resources.
Social Links
Facebook • Twitter • LinkedIn • Instagram
Want daily dose of health?
Subscribe for verified oncology updates and patient resources.
Reliable
Certified oncology medicines from trusted manufacturers.
Secure
Encrypted checkout and discreet, compliant shipping.
Affordable
Competitive pricing with patient-support programmes in selected regions.
Reviews
There are no reviews yet.