Celkeran 5 Mg (Chlorambucil)

Celkeran 5 mg (Chlorambucil)

Celkeran 5 mg contains chlorambucil, an oral alkylating chemotherapy agent used primarily in the treatment of chronic lymphocytic leukaemia (CLL) and selected lymphomas. Chlorambucil works by cross-linking DNA strands, preventing cancer cells from dividing and promoting cell death. It remains a useful option in certain patient groups, especially where tolerability and oral administration are priorities.

Celkeran is a prescription cytotoxic medicine and must be used under the care of a haematologist/oncologist with appropriate monitoring for blood counts and organ function.

Product introduction

Chlorambucil is one of the older alkylating agents in hematology oncology. It is given orally and has a long history of use in chronic lymphocytic leukaemia (CLL), some low-grade non-Hodgkin lymphomas and as palliative therapy in selected solid tumours. Its oral route and ease of administration often make it suitable for outpatient management and for patients who cannot tolerate more intensive regimens.

Choice of chlorambucil, dose and schedule depends on disease stage, patient age, comorbidities and availability of alternative targeted or immunotherapy options. Modern practice may favour targeted agents in many settings, but chlorambucil still has a role in resource-limited or specific clinical scenarios.

Uses of Celkeran 5 mg (Chlorambucil)

Common indications include:

• Chronic lymphocytic leukaemia (CLL) — especially in older or frail patients and certain maintenance approaches
• Low-grade non-Hodgkin lymphoma (indolent lymphomas) — palliative or disease-control settings
• Some specialist protocols for autoimmune haematologic conditions (off-label, specialist-directed)
• Occasional role as part of combination regimens where indicated by the treating haematologist

Note: Treatment must be individualised. Many modern regimens now include targeted agents (BTK inhibitors, BCL2 inhibitors) which may replace or complement alkylators; discuss options with your haematology team.

Benefits of Celkeran 5 mg (Chlorambucil)

Benefits of chlorambucil therapy include:

• Oral administration allows outpatient treatment and convenience for long-term disease control.
• Simpler monitoring compared with intensive IV chemotherapy in selected patients.
• Effective disease control in many patients with indolent lymphoid malignancies.
• Lower acute toxicity relative to some aggressive regimens, making it suitable for older or frailer patients.

In Treatment of Worm infections

Important: Chlorambucil is not an antiparasitic or anthelmintic — it does not treat worm infections. This heading is included to match your page structure.

Side effects of Celkeran 5 mg (Chlorambucil)

Chlorambucil has a well-documented adverse-effect profile centred on bone marrow suppression and long-term risks associated with alkylating agents.

Common side effects

• Low blood counts (neutropenia, thrombocytopenia, anaemia)
• Nausea and vomiting
• Loss of appetite and weight loss
• Fatigue
• Mouth soreness
• Skin rash and photosensitivity

Serious and long-term risks: profound bone marrow suppression with infection or bleeding risk, prolonged cytopenias, infertility (both sexes), secondary malignancies (therapy-related myelodysplastic syndrome or acute myeloid leukaemia), severe hepatic or renal toxicity in rare cases. Seek urgent medical attention for fever, bleeding, severe fatigue, sudden bruising or signs of infection.

How to use Celkeran 5 mg (Chlorambucil)

• Take chlorambucil exactly as prescribed by your haematologist.
• Typical dosing is variable — common schedules include daily low-dose or intermittent higher-dose cycles (for example, 0.1–0.2 mg/kg daily or defined mg/day for several days followed by rest). The treating specialist will select a regimen tailored to the patient.
• Swallow tablets with water; do not crush unless instructed.
• Take at the same time each day where applicable.
• Do not stop treatment without consulting your treating team — dose adjustments or temporary interruptions may be necessary for toxicity.

Regular blood tests (CBC), liver and renal function tests are essential prior to and during treatment. Monitor closely for infections or bleeding.

How Celkeran 5 mg (Chlorambucil) works

Chlorambucil is an alkylating agent that attaches alkyl groups to DNA, producing cross-links and miscoding that impede DNA replication and transcription. Cells that are rapidly dividing — such as malignant lymphocytes — are particularly susceptible, resulting in cell-cycle arrest and apoptosis. Because alkylation affects DNA broadly, chlorambucil can also damage normal rapidly dividing tissues — hence the need for careful monitoring.

Safety advice

What if you forget to take Celkeran 5 mg?

If you miss a dose, follow the clinic’s guidance or the instructions given with your prescription:

• In many regimens, take the missed dose as soon as remembered if within the same day — otherwise skip and continue the next scheduled dose.
• Do not double doses to compensate for missed tablets.
• Inform your haematology nurse if multiple doses are missed — cycle timing may need adjustment.

All substitutes

Alternatives depend on diagnosis and patient factors:

• Fludarabine, bendamustine, or chlorambucil-based combination therapies in CLL (choice depends on fitness and molecular markers)
• Targeted agents (ibrutinib, acalabrutinib, venetoclax) increasingly preferred in many CLL settings
• Other alkylators such as cyclophosphamide in certain protocols

Selection of alternatives should be guided by a haematologist and informed by molecular testing and comorbidities.

Quick tips

• Carry a treatment card listing your medication and emergency contacts.
• Avoid crowds and close contact with sick people while neutropenic.
• Report fever (≥38°C), severe cough, difficulty breathing, unusual bruising or bleeding immediately.
• Use contraception during and for a period after treatment as advised by your clinician.
• Store tablets as instructed and keep out of reach of children.

Fact Box

Patient concerns

Will Celkeran cure my disease? In indolent lymphoid malignancies, chlorambucil may control disease and improve symptoms; cure depends on disease type, stage and available therapies. Discuss realistic goals with your specialist.

How will I be monitored? Expect frequent blood counts, liver and kidney tests and clinic reviews — monitoring is essential to detect cytopenias and organ toxicity early.

User feedback

Many patients appreciate the convenience of oral therapy and the generally manageable acute side-effect profile compared with aggressive IV regimens. However, long-term risks such as marrow suppression and possible secondary cancers are important considerations discussed by clinicians before starting therapy.

Are you currently taking Celkeran 5 mg (Chlorambucil)? Please discuss any side effects or concerns with your haematology team — do not stop treatment without medical advice.

FAQs

Can I take Celkeran with other medicines?

Only under specialist instruction. Many medicines interact with cytotoxic therapy — always inform your haematology team about all prescription, OTC and herbal medicines.

Do I need fertility counselling before treatment?

Yes — chlorambucil can impair fertility. Discuss sperm or egg preservation options before starting therapy if applicable.

How long will treatment last?

Duration varies: treatment may be given as intermittent cycles or continuous low-dose regimens depending on disease control and tolerability. Your specialist will advise the expected course.

How should I store Celkeran?

Store at room temperature, protected from moisture and light. Keep out of reach of children and do not use after the expiry date.

Related products

• Fludarabine — alternative in certain CLL regimens
• Bendamustine — used for indolent lymphoma and CLL in some settings
• Targeted agents — e.g., ibrutinib, venetoclax (specialist-directed)
• View all oncology medicines

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Disclaimer:

This article is for educational purposes only and does not replace specialist haematology/oncology advice. Celkeran (chlorambucil) must be prescribed and monitored by qualified clinicians. Do not self-medicate.

References

• Haematology oncology treatment guidelines and specialist literature
• Pharmacology and long-term safety literature for alkylating agents

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For order support use live chat or our contact page. For medical concerns contact your haematology/oncology team immediately.

Lab tests offered by us

• Complete Blood Count (CBC) with differential
• Liver Function Tests (LFTs)
• Renal profile
• Fertility preservation counselling referral
• Infection screening where clinically indicated

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