Cetil 250 mg (Cefuroxime)
Cetil 250 mg contains cefuroxime, a second-generation cephalosporin antibiotic with a broader spectrum than many first-generation cephalosporins. Cefuroxime is active against a range of Gram-positive and Gram-negative bacteria and is commonly used for respiratory tract infections, ENT infections, skin and soft tissue infections, and selected urinary tract infections. It works by inhibiting bacterial cell wall synthesis, leading to bacterial death.
The 250 mg oral tablet is a commonly prescribed outpatient dose that balances efficacy and tolerability for many mild-to-moderate infections. Cetil 250 mg is prescription-only and should be used under clinical guidance.
Product introduction
Cefuroxime axetil (oral prodrug of cefuroxime) is better absorbed when taken with food and offers reliable coverage for pathogens causing community infections. Cetil 250 mg provides convenient oral therapy with an established safety profile and is often selected when broader coverage is required compared to first-generation cephalosporins.
Because antibiotic resistance patterns vary by region, cetil should be prescribed based on clinical judgment and, where possible, culture and sensitivity testing.
Uses of Cetil 250 mg (Cefuroxime)
Cetil 250 mg is used for a variety of bacterial infections, including:
- Respiratory tract infections:
- Acute bronchitis (selected cases)
- Community-acquired pneumonia (mild–moderate, depending on guidelines)
- Sinusitis
- ENT infections:
- Otitis media
- Tonsillitis and pharyngitis (when indicated)
- Skin & soft tissue infections: cellulitis, wound infections
- Uncomplicated urinary tract infections (UTIs), where susceptibility is likely
- Lyme disease (alternative regimens in some regions) — clinician-directed
- Post-dental or minor surgical prophylaxis where appropriate
Note: Cetil (cefuroxime) is not effective against viral illnesses such as the common cold or influenza.
Benefits of Cetil 250 mg (Cefuroxime)
Key benefits of using Cetil 250 mg include:
- Broader spectrum than many first-generation cephalosporins — better Gram-negative coverage.
- Good respiratory tract penetration, useful for sinusitis and bronchopulmonary infections.
- Oral formulation convenient for outpatient therapy.
- Generally well tolerated with a long clinical history.
- Useful alternative in some penicillin-allergic patients (unless allergy is severe or immediate-type).
In Treatment of Worm infections
Important: Cefuroxime does not treat parasitic or worm infections. This section is included only to keep the page structure consistent. Use antiparasitic agents for helminth infections.
Side effects of Cetil 250 mg (Cefuroxime)
Most side effects are mild and self-limiting, but serious adverse reactions can occur rarely.
Common side effects
- Gastrointestinal upset — nausea, diarrhoea
- Abdominal discomfort
- Headache
- Skin rash or itching
Serious but rare: severe allergic reactions (anaphylaxis), Clostridioides difficile infection (severe diarrhoea), blood dyscrasias, severe skin reactions (Stevens–Johnson syndrome). Seek immediate medical care for rash, swelling, breathing difficulties, high fever or persistent severe diarrhoea.
How to use Cetil 250 mg (Cefuroxime)
- Take exactly as prescribed by your healthcare provider.
- Cefuroxime axetil is best taken with food to improve absorption.
- Typical adult dosing for many infections is 250 mg twice daily (BD); follow clinician instructions for dose and duration.
- Swallow tablets whole with water; do not crush unless specifically advised.
- Complete the full course even if symptoms improve early to reduce resistance risk.
If symptoms do not improve within 48–72 hours or worsen, contact your clinician for reassessment.
How Cetil 250 mg (Cefuroxime) works
Cefuroxime interferes with bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This prevents peptidoglycan cross-linking in the cell wall, weakening structural integrity and causing lysis of dividing bacteria. Cefuroxime is bactericidal and most effective against actively dividing organisms.
Safety advice
| Allergies | Avoid if you have a known severe allergy to cephalosporins. Exercise caution if you have a history of penicillin allergy—discuss with your prescriber. |
| Pregnancy | Generally considered safe when prescribed by a clinician—discuss risks and benefits with your obstetrician. |
| Breastfeeding | Small amounts may pass into breastmilk—consult your clinician if breastfeeding. |
| Kidney disease | Dose adjustments may be required in significant renal impairment—inform your prescriber of kidney issues. |
| Drug interactions | May interact with oral anticoagulants (e.g., warfarin) increasing bleeding risk—monitor if co-prescribed. Review all medications with your pharmacist. |
| Alcohol | No specific interaction but avoid excessive alcohol while recovering from infection. |
What if you forget to take Cetil 250 mg?
If you miss a dose, take it as soon as you remember. If it is near the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.
All substitutes
Alternatives depend on the infection and organism susceptibility:
- Cefuroxime 500 mg (higher dose formulation)
- Amoxyclav (amoxicillin-clavulanate) for broader spectrum needs
- Cephalexin (first-generation cephalosporin) for certain skin infections
- Macrolides (azithromycin, clarithromycin) for penicillin-allergic patients
- Fluoroquinolones (ciprofloxacin, levofloxacin) for selected indications — consider safety and resistance
Choose substitutes only after clinician recommendation and, where feasible, culture & sensitivity guidance.
Quick tips
- Take cefuroxime with food for better absorption and fewer stomach issues.
- Finish the entire antibiotic course to prevent relapse and resistance.
- Report severe diarrhoea, jaundice or allergic symptoms immediately.
- Inform prescribers about pregnancy, breastfeeding, and current medications.
Fact Box
| Generic name | Cefuroxime (cefuroxime axetil oral prodrug) |
| Brand | Cetil 250 mg |
| Drug class | Second-generation cephalosporin |
| Form | Oral tablet (250 mg) |
| Typical dose | 250 mg twice daily (clinician directed) |
| Prescription | Required |
Patient concerns
Will Cetil treat my throat infection? If the cause is bacterial and susceptible to cefuroxime, it can be effective—confirm with your clinician.
How quickly will I feel better? Many patients report improvement within 48–72 hours; if symptoms worsen or do not improve, seek medical review.
User feedback
Patients commonly report good outcomes for sinus, ear and skin infections with acceptable tolerability. Gastrointestinal complaints are the most frequent minor side effects.
Are you currently taking Cetil 250 mg (Cefuroxime)? Let us know how well it is working for you by taking this survey.
FAQs
Can I stop Cetil once I feel better?
No — complete the full course unless advised otherwise by your clinician to reduce relapse and resistance risk.
Can I take probiotics with Cetil?
Probiotics or yogurt may help reduce antibiotic-associated diarrhoea; discuss with your clinician if you plan to use them.
Can I take antacids with cefuroxime?
Antacids do not substantially affect cefuroxime absorption, but take medications spaced as advised by your prescriber if you are on multiple drugs.
How should I store Cetil 250 mg?
Store in a cool, dry place away from direct sunlight and out of reach of children. Do not use past the expiry date.
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Disclaimer:
This article is for educational purposes only and does not replace professional medical advice. Always consult a healthcare professional before starting or stopping antibiotics.
References
- Clinical infectious disease guidelines
- Pharmacology references for cephalosporin antibiotics
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Lab tests offered by us
- Throat swab culture & sensitivity
- Urine culture & sensitivity
- Complete Blood Count (CBC)
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