Buy Endobloc 10 mg (Ambrisentan) – Pulmonary Arterial Hypertension Therapy

Endobloc 10 mg, manufactured by Cipla Ltd., contains ambrisentan, a selective endothelin A receptor antagonist used to treat WHO Group 1 pulmonary arterial hypertension (PAH), improving exercise capacity and delaying clinical worsening. 

How It Works

Ambrisentan blocks endothelin A receptors, leading to relaxation of pulmonary blood vessels, reduced vascular tone, and lowered pulmonary artery pressure to support heart function. 

Indications & Benefits

• Treats pulmonary arterial hypertension (WHO Group 1) in adults with functional Class II–III symptoms.
• Improves walking distance and exercise tolerance, delays disease progression. 
• May be combined with tadalafil for enhanced clinical benefit. 

Dosage & Administration

• Initial dose: 5 mg orally once daily, with or without food. May increase to 10 mg daily after 4 weeks if tolerated. 
• If used with cyclosporine, limit to 5 mg/day. 
• No renal dose adjustment for mild-to-moderate impairment; avoid use in moderate–severe liver disease. 
• Swallow tablet whole—do not crush or chew. 

Side Effects & Safety

• Common: peripheral edema, headache, flushing, nasal congestion, palpitations, nausea, fatigue, sinusitis. 
• Serious: anemia or elevated liver enzymes—periodic labs advised. 
• Contraindications: pregnancy (teratogenic), idiopathic pulmonary fibrosis, severe liver impairment. Women of childbearing potential must use effective contraception. 

Precautions & Interactions

• Avoid use with cyclosporine above 5 mg—or as per physician instruction. 
• Caution in patients with anemia, heart failure, kidney disease, or fluid retention. 
• May cause dizziness or fatigue—avoid driving or operating machinery until effects are known.
• Avoid abrupt discontinuation; always follow physician advice. 

Global Availability & Prescription Info

Endobloc 10 mg is prescription-only, produced by Cipla Ltd. It is available globally through licensed pharmacies with discreet, tracked shipping. Treatment must be supervised by a PAH specialist. 

📌 Frequently Asked Questions (FAQs)

1. What is Endobloc 10 mg used for?

It treats pulmonary arterial hypertension to lower lung artery pressure, improve exercise capacity, and delay clinical worsening. 

2. How should I take it?

Take one 10 mg tablet orally once daily, with or without food. Swallow whole at the same time each day—do not crush or chew. Dosage may begin at 5 mg and increase to 10 mg after 4 weeks if tolerated. 

3. What side effects are common?

Typical side effects include swelling, headache, palpitations, nasal congestion, flushing, nausea, diarrhea, or fatigue. Laboratory monitoring for anemia and liver function is necessary.

4. Who should avoid Endobloc?

Do not use during pregnancy (born defects risk) or breastfeeding. Avoid in those with pulmonary fibrosis, severe hepatic impairment, or known allergy to ambrisentan. Women of childbearing potential must use effective contraception during and one month after treatment. 

5. Can I take it with other PAH drugs?

Yes—it may be combined with tadalafil to improve outcomes. Avoid concurrent use with cyclosporine above 5 mg/day and inform your physician of all medication and health conditions.