Buy Endobloc 5 mg (Ambrisentan) – Effective Treatment for Pulmonary Arterial Hypertension

Endobloc 5 mg by Cipla contains ambrisentan, a selective endothelin A receptor antagonist used for treating WHO Group 1 pulmonary arterial hypertension (PAH). It helps improve exercise capacity and delay disease progression. 

How It Works

Ambrisentan blocks endothelin‑A receptors, relaxing pulmonary blood vessels, lowering lung artery pressure, and reducing the workload on the right heart—leading to better exercise tolerance. 

Indications & Benefits

• Treats PAH in adults (WHO FC II–IV) to enhance exercise ability and delay clinical worsening.
• Used as monotherapy or in combination with tadalafil to reduce hospitalization and disease progression. 

Dosage & Administration

• Start at 5 mg once daily, taken orally with or without food. The tablet must be swallowed whole—not crushed or chewed. 
• If tolerated after four weeks, the dose may be increased to 10 mg daily. Maximum dose is 10 mg/day. 
• No dosage adjustment is recommended for mild-to-moderate renal impairment. Use caution in severe cases. Not recommended for moderate-severe hepatic impairment. 
• When co-administered with cyclosporine A, limit to 5 mg daily and monitor carefully. 

Side Effects & Monitoring

• Common: headache, flushing, nasal congestion, palpitations, nausea, dizziness, fatigue, anemia, peripheral edema. 
• Fluid retention can worsen heart failure—monitor weight and signs of edema. 

Precautions & Contraindications

• Contraindicated during pregnancy and in women not using reliable contraception—teratogenicity risk is high. A REMS program applies. Monthly pregnancy tests are required for women of reproductive potential. 
• Avoid use in idiopathic pulmonary fibrosis, severe liver disease, and known allergy to ambrisentan. 
• Caution in anemia or hepatic enzyme elevation—regular lab monitoring recommended. 
• Avoid alcohol until tolerability is confirmed—can increase dizziness or hypotension. 
• Driving or operating machinery may be affected due to dizziness or fatigue. 

Global Availability & Prescription Info

Endobloc 5 mg is a prescription-only medicine manufactured by Cipla. It’s available globally through licensed pharmacies with discreet, tracked shipping. Treatment must be supervised by a PAH specialist. 

📌 Frequently Asked Questions (FAQs)

1. What is Endobloc 5 mg used for?

It is used to treat pulmonary arterial hypertension in adults to improve exercise ability and delay disease worsening. Can be monotherapy or combined with tadalafil. 

2. How long does it take to work?

Onset is not precisely defined; consistent daily use over weeks improves symptoms and exercise tolerance. 

3. What side effects might occur?

Common: headache, flushing, dizziness, anemia, edema. Serious: fluid overload in heart disease, elevated liver enzymes. Report symptoms promptly. 

4. Can pregnant women take it?

No—it causes fetal harm. Women of reproductive potential must enroll in REMS, use effective contraception, and undergo monthly pregnancy tests during and 3 months after treatment.

5. What if I miss or overdose a dose?

If missed, take as soon as remembered the same day. Do not double dose. Overdose may cause headache, dizziness, flushing, low blood pressure—seek medical help for severe symptoms.