Evermil 5 mg (Everolimus)
Evermil 5 mg contains everolimus, an oral mammalian target of rapamycin (mTOR) inhibitor used in oncology and transplant medicine. Everolimus blocks the mTOR pathway, inhibiting cell proliferation, angiogenesis and survival signals in certain tumours, and suppresses immune activation to reduce risk of organ rejection in transplant patients.
Evermil 5 mg is a specialist prescription medicine and must be used under oncology or transplant specialist supervision with regular laboratory monitoring and clinical follow-up.
Product introduction
Everolimus is a targeted therapy derived from sirolimus (rapamycin). In oncology it is indicated for several tumour types (e.g., advanced renal cell carcinoma, certain neuroendocrine tumours, hormone receptor-positive breast cancer in combination regimens, tuberous sclerosis complex [TSC]-related tumours). In transplantation, it is used as an adjunct immunosuppressant to prevent rejection after kidney, liver or heart transplantation in selected protocols.
Because everolimus affects immune function and wound healing, treatment initiation, dosing adjustments and duration should follow specialist guidance tailored to the indication and patient factors.
Uses of Evermil 5 mg (Everolimus)
Typical clinical indications include:
- Advanced renal cell carcinoma (after prior VEGF targeted therapy or in combination where approved)
- Advanced pancreatic, gastrointestinal or lung neuroendocrine tumours (progressive, well-differentiated)
- Hormone receptor–positive HER2-negative advanced breast cancer (in combination with endocrine therapy, where indicated)
- Tuberous sclerosis complex (TSC) related renal angiomyolipoma and subependymal giant cell astrocytoma (SEGA)
- Prevention of organ rejection in select kidney, liver, or heart transplant regimens (specialist-directed)
Note: Exact licensed indications vary by country and brand. Use only under prescription and specialist supervision.
Benefits of Evermil 5 mg (Everolimus)
Clinical benefits depend on the condition treated:
- Tumour control: can slow progression and stabilise disease in responsive cancers.
- Oral administration: convenient outpatient therapy compared with some IV regimens.
- Immunosuppression option: enables maintenance regimens in transplantation with steroid- or calcineurin-sparing strategies in certain protocols.
- Targeted mechanism: useful when tumours have mTOR pathway involvement or TSC mutations.
In Treatment of Worm infections
Important: Everolimus is not an antiparasitic drug and does not treat worm infections. This heading is included to maintain your page template.
Side effects of Evermil 5 mg (Everolimus)
Everolimus has a characteristic safety profile. Many side effects are manageable with monitoring and supportive care, but some can be serious.
Common side effects
- Mouth ulcers (stomatitis)
- Infections (due to immunosuppression)
- Fatigue, weakness
- Diarrhoea, nausea
- Stomatitis and mucositis
- Rash or acneiform eruptions
- Edema, peripheral or pulmonary
Serious but important risks: non-infectious pneumonitis (may present with cough, breathlessness, hypoxia), severe infections including opportunistic infections, impaired wound healing, thrombocytopenia or neutropenia, hyperglycaemia, hyperlipidaemia, renal impairment (especially in combination with other nephrotoxic drugs), and severe hypersensitivity reactions. Monitor and report breathlessness, persistent cough, fever, severe mouth ulcers, bleeding, or signs of infection immediately.
How to use Evermil 5 mg (Everolimus)
- Take exactly as prescribed by your treating specialist.
- Dosage varies by indication — common starting doses for oncology are 5–10 mg once daily depending on indication and tolerability; transplant doses differ (specialist-directed).
- Take whole tablets at the same time each day; do not crush.
- With or without food — some regimens recommend consistent relation to meals; follow clinician instructions.
- Do not stop therapy abruptly without medical advice — abrupt cessation may be appropriate in severe toxicity but should be supervised.
Adjustment for drug interactions, liver impairment, or specific toxicities is common—specialist oversight is required.
How Evermil 5 mg (Everolimus) works
Everolimus binds to the intracellular protein FKBP12 to form a complex that inhibits mTOR complex 1 (mTORC1). This inhibition reduces protein synthesis, cell growth and angiogenesis, and modulates immune cell proliferation. In oncology, blocking mTOR impairs tumour cell survival and proliferation; in transplantation, it dampens T-cell activation to reduce rejection risk.
Safety advice
| Allergies | Avoid if known hypersensitivity to everolimus, sirolimus or any excipient. |
| Pregnancy | May cause fetal harm. Women of childbearing potential must use effective contraception; discuss risks with specialist. |
| Breastfeeding | Unknown if excreted in human milk—breastfeeding is not recommended during treatment. |
| Infections | Avoid live vaccines while on therapy. Treat infections promptly and consider prophylactic strategies per specialist guidance. |
| Lung disease | Non-infectious pneumonitis is a recognised risk—report new/worsening cough or breathlessness immediately. |
| Liver impairment | Dose adjustments may be needed — monitor LFTs and consider lower starting doses in hepatic impairment. |
| Drug interactions | Strong CYP3A4 inhibitors (e.g., certain azoles, macrolides, protease inhibitors) increase everolimus exposure; strong inducers reduce levels. Review all medications, including herbal products (e.g., St. John’s Wort). |
| Wound healing | May impair wound healing — consider holding therapy around major surgery per surgeon/oncologist recommendation. |
What if you forget to take Evermil 5 mg?
If you miss a dose, take it as soon as you remember the same day. If it is almost time for the next dose, skip the missed dose. Do not double the dose. For transplant patients, adherence is critical—contact your transplant team if multiple missed doses occur.
All substitutes
Substitute choice depends on indication:
- Sirolimus (rapamycin) — alternative mTOR inhibitor in some transplant settings
- Temsirolimus — IV mTOR inhibitor used in certain oncology indications
- Targeted agents or different immunosuppressive classes (calcineurin inhibitors, antimetabolites) depending on transplant protocol or cancer type
Switching therapies requires specialist oversight and often therapeutic drug monitoring or protocolised crossover.
Quick tips
- Report signs of infection (fever, chills) immediately.
- Keep scheduled blood tests including CBC, LFTs, renal profile, fasting glucose and lipids.
- Inform all healthcare providers (dentists, surgeons) that you are taking everolimus — plan wound care and vaccine timing accordingly.
- Avoid grapefruit and grapefruit juice — they can increase drug levels.
Fact Box
| Generic name | Everolimus |
| Brand | Evermil 5 mg |
| Drug class | mTOR inhibitor (targeted therapy / immunosuppressant) |
| Form | Oral tablet (5 mg) |
| Typical dose | Varies by indication — commonly 5–10 mg once daily in oncology; transplant dosing differs (specialist-directed) |
| Prescription | Required (oncology / transplant specialist) |
Patient concerns
Will Evermil cure my cancer? Everolimus can control disease and delay progression in selected cancers, but outcomes depend on tumour type, stage, prior therapies and individual response. Discuss prognosis and goals of therapy with your oncologist.
Is it safe long-term? Long-term use is possible but requires careful monitoring for infections, metabolic changes and organ-specific toxicities. Balance of benefits vs risks is assessed regularly by specialists.
User feedback
Patients report clinical benefits in tumour control or prevention of transplant rejection when used appropriately. Common patient complaints include mouth ulcers, fatigue, GI upset and increased susceptibility to minor infections. Many side effects are manageable with supportive measures or dose adjustments.
Are you currently taking Evermil 5 mg (Everolimus)? Share your experience with your treating team to help optimise therapy and manage side effects.
FAQs
Can I take Evermil with other cancer drugs?
Yes — everolimus is often used in combination regimens. Interactions and combined toxicities must be managed by your oncology team; do not combine without specialist approval.
Do I need blood tests while on Evermil?
Yes — regular CBC, liver and renal function tests, fasting glucose and lipid profiles are commonly required. Frequency depends on indication and clinical status.
Can I get vaccinated while taking Evermil?
Avoid live vaccines while on immunosuppressive doses of everolimus. Inactivated vaccines may be given but responses can be reduced; discuss timing with your clinician.
How should I store Evermil?
Store at room temperature, protected from moisture and heat. Keep out of reach of children and do not use after the expiry date.
Related products
- View oncology medicines
- Transplant immunosuppressants
- Supportive care medicines (antimicrobials, antiemetics)
Want to share the information?
Share this article to help patients and caregivers understand everolimus therapy and safe use.
Disclaimer:
This article is for educational purposes only and does not replace specialist medical advice. Evermil (everolimus) must be prescribed and monitored by qualified oncology or transplant teams. Do not self-medicate.
References
- Clinical prescribing information for everolimus and specialist oncology guidelines
- Transplant immunosuppression protocols and monitoring recommendations
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