Exesin 25 mg (Exemestane)
Exesin 25 mg contains exemestane, an oral irreversible aromatase inhibitor used in the treatment of hormone receptor–positive (ER+/PR+) breast cancer in postmenopausal women. Exemestane lowers estrogen production by blocking the aromatase enzyme, reducing tumour growth that depends on oestrogen signalling.
Exemestane is commonly used in adjuvant, extended adjuvant and metastatic settings and should be prescribed and monitored by an oncologist or breast cancer specialist.
Product introduction
Exemestane is a steroidal (irreversible) aromatase inactivator. The standard oral dose is 25 mg once daily. It is indicated for postmenopausal women with ER-positive early breast cancer (often after 2–3 years of tamoxifen) or for metastatic disease where aromatase inhibitors are appropriate. It may also be part of combination endocrine strategies according to clinical judgment.
Treatment decisions depend on menopausal status, prior endocrine therapy, comorbidities, and bone health. Specialist supervision is essential.
Uses of Exesin 25 mg (Exemestane)
Exemestane is prescribed for:
- Adjuvant therapy for early hormone receptor–positive breast cancer in postmenopausal women.
- Extended adjuvant therapy following initial tamoxifen (to reduce recurrence risk).
- Treatment of advanced or metastatic ER+ breast cancer in postmenopausal women.
- Endocrine therapy in selected patients based on tumour biology and prior treatments.
Note: Exemestane is not effective in premenopausal women unless combined with ovarian suppression; discuss options with your oncologist.
Benefits of Exesin 25 mg (Exemestane)
Clinical advantages include:
- Effective estrogen suppression in postmenopausal women leading to reduced recurrence risk.
- Oral once-daily dosing for convenience.
- Shown benefit in adjuvant and metastatic settings.
- Option after tamoxifen for extended therapy to further lower relapse risk.
In Treatment of Worm infections
Important: Exemestane is not an antiparasitic or anthelmintic. This heading is included only to preserve the page structure.
Side effects of Exesin 25 mg (Exemestane)
Many patients tolerate exemestane well, but there is a recognised side-effect profile; bone health and musculoskeletal symptoms are notable.
Common side effects
- Hot flashes, night sweats
- Joint pain (arthralgia) and muscle aches
- Fatigue
- Vaginal dryness or sexual dysfunction
- Nausea
- Headache
Important risks: decreased bone mineral density and increased fracture risk, hypercholesterolaemia, mood changes, and rare liver enzyme elevations. Seek medical advice for new or severe bone pain, signs of fracture, or significant mood changes.
How to use Exesin 25 mg (Exemestane)
- Take 25 mg once daily, preferably after a meal, or exactly as your oncologist prescribes.
- Swallow the tablet whole with water.
- Do not stop therapy without discussing with your treating team — sudden cessation may affect treatment outcomes.
- Bone-protective measures (calcium, vitamin D, weight-bearing exercise) and baseline/follow-up DEXA scans are commonly recommended.
- If you are premenopausal, exemestane is usually given only with ovarian suppression (goserelin/leuprolide) — follow specialist guidance.
Report any unexplained bone pain, severe musculoskeletal symptoms, or signs of deep vein thrombosis immediately.
How Exesin 25 mg (Exemestane) works
Exemestane irreversibly binds and inactivates the aromatase enzyme that converts androgens to estrogens in peripheral tissues. By reducing circulating estrogen levels, exemestane deprives ER-positive breast cancer cells of a key growth stimulus, slowing tumour progression.
Safety advice
| Pregnancy | Contraindicated. Exemestane may cause fetal harm; women of childbearing potential must use effective contraception and avoid pregnancy during treatment. |
| Breastfeeding | Do not breastfeed while taking exemestane. |
| Bone health | Monitor bone mineral density (DEXA). Consider calcium and vitamin D supplementation and lifestyle measures; bisphosphonates or denosumab may be indicated for high fracture risk. |
| Lipid profile | Exemestane can increase cholesterol; monitor lipids and manage per guidelines. |
| Liver disease | Use with caution in significant hepatic impairment; monitor LFTs. |
| Drug interactions | Review other medicines with your oncologist or pharmacist — some CYP3A4 inducers or inhibitors may alter exemestane exposure. |
What if you forget to take Exesin 25 mg?
If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next scheduled dose, skip the missed dose. Do not double the dose.
All substitutes
Alternative endocrine options (choice depends on prior therapy, menopausal status and tumour factors):
- Anastrozole (non-steroidal aromatase inhibitor)
- Letrozole (non-steroidal aromatase inhibitor)
- Tamoxifen (selective oestrogen receptor modulator) — often used in premenopausal women
- Fulvestrant (selective oestrogen receptor degrader) for certain metastatic settings
Switching agents should be guided by your oncology specialist.
Quick tips
- Maintain bone-healthy lifestyle: weight-bearing exercise, smoking cessation, limit alcohol.
- Ensure adequate calcium and vitamin D intake; discuss supplements with your clinician.
- Report persistent joint pain — symptomatic treatment or switching therapy may be considered.
- Attend scheduled blood tests and DEXA scans as advised.
Fact Box
| Generic name | Exemestane |
| Brand | Exesin 25 mg |
| Drug class | Steroidal aromatase inhibitor (irreversible) |
| Form | Oral tablet (25 mg) |
| Typical dose | 25 mg once daily (postmenopausal women; clinician directed) |
| Prescription | Required (oncology/breast specialist) |
Patient concerns
Will Exesin cure my breast cancer? Exemestane is an effective component of endocrine therapy aimed at reducing recurrence and controlling hormone-driven disease. Cure depends on stage, biology and overall treatment plan — discuss prognosis with your oncologist.
How soon will I notice effects? Endocrine therapy reduces recurrence risk over months to years; symptom changes (e.g., hot flashes, joint pain) may be noticed early. Tumour response is assessed via imaging and tumour markers as appropriate.
User feedback
Many patients tolerate exemestane well and appreciate once-daily oral dosing. Joint pain and bone-thinning are common concerns; proactive bone monitoring and supportive care reduce long-term risks.
Are you currently taking Exesin 25 mg (Exemestane)? Let us know how it is working for you by taking this survey.
FAQs
Can men take exemestane?
Exemestane is occasionally used off-label in men for hormone-sensitive conditions; use only under specialist guidance.
Can I take exemestane if I am premenopausal?
Exemestane is generally for postmenopausal women. In premenopausal women, it may be used only with ovarian suppression (LHRH agonists) under specialist supervision.
Does exemestane cause weight gain?
Weight changes can occur with endocrine therapy; lifestyle measures and monitoring are recommended. Discuss significant weight changes with your clinician.
How should I store Exesin?
Store at room temperature away from moisture and heat. Keep out of reach of children and do not use past expiry.
Related products
- Anastrozole 1 mg
- Letrozole 2.5 mg
- View all oncology & endocrine therapies
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Disclaimer:
This article is for educational purposes only and does not replace specialist medical advice. Exemestane (Exesin 25 mg) must be prescribed and monitored by a qualified oncology or breast-cancer team. Do not self-medicate.
References
- Breast cancer endocrine therapy guidelines and specialist oncology literature
- Pharmacology references for aromatase inhibitors
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Lab tests offered by us
- Bone mineral density scan (DEXA)
- Serum lipids
- Liver function tests (LFTs)
- Baseline and follow-up blood tests as directed
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