Description

Irovel 300 mg (Irbesartan) – Maximum ARB Dose for Hypertension & Diabetic Kidney Protection

Irovel 300 mg contains irbesartan, an Angiotensin II Receptor Blocker (ARB). It is used to treat moderate-to-severe hypertension and to slow kidney disease progression in adults with type 2 diabetes and hypertension. 

Key Benefits:

• Controls blood pressure effectively at maximum 300 mg once daily
• Protects kidney function in type 2 diabetic patients with proteinuria or elevated creatinine
• May reduce risk of stroke, myocardial infarction and heart failure progression

How It Works

Irbesartan blocks AT₁ angiotensin II receptors, leading to vasodilation, reduced aldosterone, and decreased fluid retention—thus lowering BP and protecting renal function. 

Dosage & Administration

The typical **maintenance dose is 300 mg once daily**, with or without food. Therapy is generally started at **150 mg/day**, with increases after monitoring, or initiated at **75 mg/day** in frail, volume-depleted, renal‑impaired, or elderly patients. (Max dose: 300 mg/day.) 

Common Side Effects

• Dizziness (especially on standing), fatigue, headache, nausea, diarrhea, heartburn
• Hyperkalemia, orthostatic hypotension, angioedema (rare but serious) 

Precautions & Interactions

• **Contraindicated in pregnancy** due to risk of fetal harm; also not recommended while breastfeeding. )
• Avoid use with aliskiren in diabetic patients; avoid potassium supplements, potassium-sparing diuretics, NSAIDs, or lithium due to increased risks. 
• No dosage adjustment needed in mild-to-moderate renal or hepatic dysfunction unless volume depleted. Initiate lower dose (75 mg) in hemodialysis or elderly (>75 years). 

Why Choose Irovel 300 mg?

• Sun Pharma’s high-strength generic ensures consistent efficacy across hypertension and diabetic nephropathy indications 
• Maximum once-daily dosing simplifies regimen and provides sustained control
• Well-documented renal protection and cardiovascular safety profile

Frequently Asked Questions (FAQs)

1. Who should receive the 300 mg dose?

Adults with uncontrolled hypertension on 150 mg, or type 2 diabetics with proteinuria/kidney disease where renal protection is indicated.

2. How long before it works?

Blood pressure reduction begins within 1–2 hours; full therapeutic effect can take 2–4 weeks. 

3. What if I miss a dose?

Take it as soon as remembered unless it’s close to next dose. Skip missed dose if too late—do not double dose. 

4. Can I take it at any time of day?

Yes—after the initial dose (possibly at bedtime due to dizziness risk), you can take it at any consistent time with or without meals. 

5. What monitoring is needed?

Periodic checks of blood pressure, kidney function, serum potassium, and liver enzymes are recommended. Monitor more closely during dose escalation or if combining with diuretics.