Description

Kerendia 20 mg (Finerenone) – Target Dose for Kidney and Heart Protection

Kerendia 20 mg provides the recommended target dose of finerenone—used to reduce kidney function decline, prevent end-stage kidney disease, and lower cardiovascular death, myocardial infarction, and heart failure hospitalization in adults with CKD associated with type 2 diabetes. 

Key Benefits:

• Official target maintenance dose shown to reduce CKD progression and cardiovascular outcomes in FIDELIO‑DKD and FIGARO‑DKD trials 
• Once‑daily dosing improves adherence and consistency
• Provides anti‑inflammatory and anti‑fibrotic effects via MR antagonism 

How It Works

Finerenone blocks mineralocorticoid receptors to reduce inflammation and fibrosis in kidney and heart tissues, slowing disease progression in T2D‑associated CKD. 

Recommended Dosage

• Patients with eGFR ≥ 60 mL/min/1.73 m²: start directly at 20 mg once daily.
• Patients with eGFR 25–< 60: start at 10 mg once daily, increase to 20 mg after 4 weeks if potassium ≤ 4.8 mEq/L. 

Monitoring & Dose Adjustments

• Check serum potassium and eGFR at baseline and again at 4 weeks after initiation or dose change. 
• Adjust dose based on potassium: ≤ 4.8 ⇒ maintain 20 mg > 4.8–5.5 ⇒ maintain current dose > 5.5 ⇒ withhold until < 5.0 mEq/L then restart at 10 mg. 

Common Side Effects

• Hyperkalemia (elevated potassium), hypotension, hyponatremia—most common effects. 
• Low blood pressure symptoms (dizziness), fatigue or headache occasionally observed.

Precautions & Interactions

• Do not initiate if serum potassium > 5.0 mEq/L. 
• Avoid strong CYP3A4 inhibitors or inducers and grapefruit juice. 
• Not recommended in severe hepatic impairment (Child‑Pugh C) or eGFR < 25 mL/min/1.73 m². 

Why Choose Kerendia 20 mg?

• Established RCT‑based target dose with proven outcomes for CKD and cardiovascular risk in T2D. 
• Bayer’s well‑studied non‑steroidal MR antagonist with once‑daily convenience

Frequently Asked Questions (FAQs)

1. Who should be on Kerendia 20 mg?

Adults with CKD and T2D, especially those with eGFR ≥ 60 or those tolerated lower dose escalating safely under monitoring. 

2. What if potassium is too high at 4‑week check?

If > 5.5 mEq/L, hold therapy and restart with 10 mg once daily once potassium falls ≤ 5.0 mEq/L. 

3. What to do if a dose is missed?

Take it as soon as remembered—but only the same day. Skip if delayed. Do not double dose. 

4. Can Kerendia be crushed?

Yes—tablets may be crushed and mixed with water or soft foods immediately before administration. 

5. Is fasting necessary?

No—it may be taken with or without food. Grapefruit juice should be avoided.