Luporal (Tegafur 100 mg / Uracil 224 mg)
Luporal contains a fixed-dose combination of tegafur (a prodrug of 5-fluorouracil) and uracil (a DPD inhibitor). This combination enhances the anticancer effect of 5-FU by preventing its rapid breakdown, resulting in improved and sustained therapeutic activity. Luporal is an oral fluoropyrimidine chemotherapy used mainly in colorectal cancer as part of systemic therapy.
This medicine must be used only under oncology supervision due to its cytotoxic effects and monitoring requirements.
Product introduction
Luporal (Tegafur/Uracil) delivers continuous oral fluoropyrimidine exposure similar to 5-FU infusion. Tegafur is converted into the active anticancer drug 5-fluorouracil, while uracil competitively inhibits dihydropyrimidine dehydrogenase (DPD), the enzyme responsible for 5-FU inactivation. This synergy ensures sustained therapeutic concentration with oral dosing.
Luporal is used in palliative, adjuvant and combination chemotherapy protocols depending on cancer stage and patient profile.
Uses of Luporal (Tegafur/Uracil)
Luporal is prescribed for the treatment of:
- Colorectal cancer (locally advanced or metastatic)
- As an oral alternative to 5-FU infusion therapy
- Combination therapy with leucovorin in some regimens
- Post-surgical adjuvant therapy (oncologist-directed)
Note: Not for minor conditions — this is an oncology cytotoxic agent requiring expert management.
Benefits of Luporal (Tegafur/Uracil)
Key benefits include:
- Oral alternative to intravenous 5-FU infusion
- Enhanced efficacy via DPD inhibition by uracil
- Sustained fluoropyrimidine exposure improving tumor control
- Convenient dosing for outpatient therapy
- Effective colorectal cancer regimen alone or with leucovorin
In Treatment of Worm infections
Important: Luporal is NOT used for parasitic or worm infections. This section is included only to match your standardized Shopify structure.
Side effects of Luporal
Side effects are common with fluoropyrimidine-based chemotherapy and must be managed proactively.
Common side effects
- Nausea, vomiting
- Loss of appetite
- Diarrhoea
- Fatigue or weakness
- Mouth sores (mucositis)
- Skin changes or darkening
Serious but clinically important risks: severe diarrhoea, myelosuppression (low white cells, platelets, or anemia), liver toxicity, cardiotoxicity, hand-foot syndrome (palmar-plantar erythrodysesthesia), dehydration, and DPD deficiency–related toxicity. Immediate medical attention is required for high fever, persistent vomiting, bleeding, severe abdominal pain, chest pain, or signs of infection.
How to use Luporal
- Take exactly as prescribed by your oncologist.
- Often taken in divided doses (e.g., 2–3 times daily).
- Swallow tablets whole with water.
- Take with or without food — follow your clinician’s specific instructions.
- Do not change dose or schedule yourself.
For best results, maintain hydration and report any severe GI symptoms immediately.
How Luporal works
Tegafur is converted into 5-fluorouracil (5-FU), which inhibits thymidylate synthase and interferes with DNA synthesis in rapidly dividing tumor cells. Uracil inhibits the enzyme DPD, slowing 5-FU breakdown and increasing its effectiveness.
Safety advice
| Pregnancy | Contraindicated — causes fetal harm. Effective contraception required. |
| Breastfeeding | Not recommended during therapy. |
| Liver monitoring | Regular LFTs are required due to risk of hepatotoxicity. |
| Blood counts | Frequent CBC monitoring is mandatory due to risk of bone marrow suppression. |
| Kidney issues | Dose adjustment may be needed in renal impairment. |
| Drug interactions | Avoid warfarin, phenytoin, and other hepatically metabolized medicines unless supervised. |
What if you forget to take Luporal?
Follow your oncologist’s instructions. In most cases:
- Take it as soon as you remember
- Skip if almost time for next dose
- Never double the dose
All substitutes
Alternatives depend on cancer stage and treatment goals:
- Capecitabine (oral fluoropyrimidine)
- 5-FU + Leucovorin IV regimens
- FOLFOX / FOLFIRI regimens
- Capecitabine + Oxaliplatin (XELOX)
Substitution must be decided by an oncologist.
Quick tips
- Report mouth sores, severe diarrhea or fever immediately.
- Avoid alcohol to reduce liver stress.
- Maintain hydration throughout therapy.
- Never skip blood tests — they are essential for safe dosing.
Fact Box
| Generic name | Tegafur + Uracil |
| Brand | Luporal |
| Drug class | Oral fluoropyrimidine anticancer therapy |
| Form | Oral tablets |
| Use | Colorectal cancer treatment |
| Prescription | Required (oncology) |
Patient concerns
Will Luporal cure my cancer? Outcomes depend on stage, treatment plan, and combination therapy. Luporal helps control tumor growth but cure depends on many clinical factors.
How long before I see improvement? Response is monitored through scans, tumor markers and clinical symptoms over multiple cycles.
User feedback
Patients commonly report improved convenience compared to IV chemotherapy. Gastrointestinal side effects and fatigue are frequently described, but manageable with medical guidance.
Are you currently taking Luporal? Share feedback with your oncology team for tailored support.
FAQs
Can I take Luporal with food?
Yes, but follow your oncologist’s instructions for optimal absorption and tolerability.
Is it safer than IV 5-FU?
It offers similar benefits but still carries chemotherapy risks. Monitoring is essential.
Can I travel while taking Luporal?
Yes, but keep medication with you and maintain scheduled blood tests.
How should I store Luporal?
Store at room temperature away from light and moisture.
Related products
- Capecitabine (Xeloda)
- 5-FU + Leucovorin kits
- Oxaliplatin (FOLFOX regimens)
- View all oncology medicines
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Disclaimer:
This article is for educational purposes only and does not replace oncologist guidance. Luporal (Tegafur/Uracil) must only be used under specialist management with regular monitoring.
References
- Fluoropyrimidine oncology protocols
- Pharmacology of Tegafur/Uracil combination
- Colorectal cancer clinical guidelines
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