Buy Rioci 1.5 mg (Riociguat) – Effective Therapy for Pulmonary Hypertension

Rioci 1.5 mg is a prescription-strength tablet containing riociguat, a soluble guanylate cyclase (sGC) stimulator for treating pulmonary arterial hypertension (PAH, WHO Group 1) and inoperable or persistent chronic thromboembolic pulmonary hypertension (CTEPH, Group 4). It improves exercise capacity and delays disease progression. 

How It Works

Riociguat directly stimulates sGC while also sensitizing it to endogenous nitric oxide. This raises cGMP levels, leading to vasodilation of pulmonary vasculature, reduced vascular resistance, and improved cardiac output. 

Indications & Benefits

• Indicated for adults with PAH or inoperable/persistent CTEPH to improve exercise tolerance and WHO functional class. 
• Proven efficacy in Phase III trials (PATENT‑1/2 and CHEST‑1/2) with sustained long-term outcomes. 

Dosage & Administration

• Initial dose: 1 mg orally **three times daily**; consider 0.5 mg TID for hypotension-prone patients.
• Titrate by 0.5 mg increments every 2 weeks based on systolic blood pressure ≥95 mmHg and tolerability, up to maximum 2.5 mg TID (total 7.5 mg daily). 
• Preferably taken at 6–8 hour intervals with or without food. Antacids containing aluminium or magnesium should be taken ≥1 hour before or after.  
• If treatment is interrupted ≥3 days, restart with 1 mg TID and retitrate. 

Common Side Effects & Monitoring

• Very common (≥ 10 %): headache (up to 27 %), dizziness (20 %), dyspepsia/gastritis, diarrhea, nausea, hypotension, peripheral edema, cough, anemia. 
• Monitor blood pressure every 2 weeks during titration. Periodic renal and liver testing advised. 
• Serious risks: bleeding events (including hemoptysis), hypotensive episodes, pulmonary edema. 

Precautions & Interactions

• Contraindicated in pregnancy and women not using reliable contraception—teratogenicity risk requires REMS pregnancy testing and registration. 
• Avoid concomitant use with nitrates, nitric oxide donors, PDE‑5 inhibitors (e.g. sildenafil, tadalafil), dipyridamole or theophylline due to risk of severe hypotension. 
• Smoking induces CYP1A1/CYP3A4 metabolism, requiring higher doses; dose may need reduction if smoking is stopped. 
• Use caution in severe renal (CrCl < 15 mL/min) or hepatic impairment (Child‑Pugh C). Elderly patients are more sensitive to hypotensive effects. 

Global Availability & Prescription Info

Rioci 1.5 mg is prescription-only and available globally via licensed pharmacies. Female patients of childbearing potential must enroll in a pregnancy-risk program (REMS). Treatment supervision by a specialist in pulmonary hypertension is essential. 

📌 Frequently Asked Questions (FAQs)

1. What is Rioci 1.5 mg used for?

It treats pulmonary arterial hypertension (PAH) and inoperable or persistent chronic thromboembolic pulmonary hypertension (CTEPH), improving exercise capacity and delaying functional decline. 

2. How long does it take to work?

Benefits in exercise tolerance and hemodynamics may appear over weeks; dosing adjustments occur every 2 weeks based on blood pressure and tolerability. 

3. What side effects are common?

Most frequent: headache, dizziness, nausea, diarrhea, hypotension, swelling, cough, and anemia. Serious side effects include bleeding and pulmonary edema. 

4. What if I miss a dose?

Skip the missed dose and continue with the next scheduled one. Do not double up. If ≥3 days missed, restart at 1 mg TID with retitration plan. 

5. Can I drink alcohol or take other medication with Rioci?

Avoid alcohol if dizzy. Do not use nitrates, PDE‑5 inhibitors, dipyridamole, or theophylline along with Rioci due to risk of severe low blood pressure. Discuss all medications with your physician.