Description

Silectone 50 mg (Spironolactone) – Fluid Control & Blood Pressure Support

Silectone 50 mg Tablet contains spironolactone—a potassium‑sparing diuretic (aldosterone antagonist) widely used in India for managing fluid retention, resistant hypertension, and heart failure. 

How Silectone Works

It competitively inhibits aldosterone at the distal renal tubules, reducing sodium and water retention while conserving potassium—making it especially useful in conditions associated with fluid overload. 

Approved Uses

• Treats resistant or secondary hypertension when standard therapy is insufficient
• Reduces edema due to heart failure, cirrhosis, nephrotic syndrome or kidney disease
• Improves survival and symptoms in heart failure with reduced ejection fraction (RALES trial)
• Treats primary hyperaldosteronism and prevents post‑surgical rebound hypertension

Also used off‑label for hormonal acne, hirsutism, idiopathic edema, and polycystic ovary syndrome—with special caution in men due to side-effect profile.

Dosage & Administration

Adults usually start at 25–50 mg once daily. In resistant cases or severe edema, doses may be titrated to 100–200 mg/day in single or divided doses. Most patients tolerate 50 mg daily maintenance dose well. 

Take once daily—preferably after breakfast. Split dosing may be used for doses >100 mg. Monitor renal function and serum potassium routinely. 

Side Effects

• Hyperkalemia (common in elderly or renal impairment)—monitor electrolytes regularly 
• Gynecomastia, breast tenderness, menstrual irregularities (dose-dependent, more common at ≥100 mg) 
• Dizziness, low blood pressure, nausea, headache, urination changes

Precautions & Interactions

• Contraindicated in hyperkalemia (supine K⁺ > 5.5 mEq/L), anuria, acute renal failure, Addison’s disease, and concomitant use with eplerenone 
• Use caution with ACE inhibitors, ARBs, potassium supplements, NSAIDs, trimethoprim, and lithium—these increase hyperkalemia risk 
• Avoid sudden withdrawal—taper slowly to prevent rebound edema or hypertension
• Not recommended during pregnancy or breastfeeding due to hormonal effects and fetal risk 

Why Choose Silectone?

• Trusted 50 mg strength provides flexibility in titration and long-term use
• Cost-effective Indian brand available via Johnlee (Torrent subsidiary), widely stocked in pharmacies 
• Essential medicine with well-characterized safety when monitored appropriately

Frequently Asked Questions (FAQs)

1. When should I take Silectone—the morning or evening?

Take in the morning after a meal to reduce pre-prandial hypotension and help manage night-time urination risk. Splitting doses may require an afternoon dose before 4 pm. 

2. Is routine potassium monitoring required?

Yes—especially at therapy initiation and dose changes. In patients with healthy renal function on ≤50 mg/day, potassium elevation is uncommon but still recommended every 1–2 months initially. 

3. Can women considering pregnancy use it?

No—spironolactone has anti‑androgen effects that may harm male fetuses. Women of reproductive age should use contraception and discuss alternatives. 

4. What if Silectone doesn’t control my blood pressure? 

If blood pressure remains elevated, it is often added to other antihypertensives (e.g., ACE inhibitors, calcium channel blockers) as per guidelines for resistant hypertension. 

5. Are there benefits in patients with cirrhosis?

Yes—aldosterone-mediated sodium retention contributes to ascites in cirrhosis. Low-dose spironolactone is first-line in such cases, often combined with furosemide.