Ticasprin 90 mg (Ticagrelor) – Dual Antiplatelet Therapy for Cardiovascular Protection

Ticasprin 90 mg contains ticagrelor, a reversible oral P2Y₁₂ receptor antagonist used to prevent blood clots and reduce risks of heart attack, stroke, or stent thrombosis in patients with acute coronary syndrome (ACS) or coronary artery disease.

Key Benefits:

• Reduces risk of myocardial infarction (heart attack) and stroke
• Approved for use in ACS and for secondary prevention after stenting
• Reversible platelet inhibition, preferred before surgery or in high-risk bleeding contexts

How It Works

Ticagrelor reversibly blocks the P2Y₁₂ ADP-receptor on platelets, preventing them from aggregating and forming clots. It provides faster onset and offset than clopidogrel without requiring hepatic activation.

Recommended Dosage

Initial loading dose of 180 mg, followed by maintenance dosing of 90 mg twice daily (often with low-dose aspirin 75 – 100 mg daily) for up to 12 months post‑ACS, then reduced to 60 mg twice daily as advised.

Possible Side Effects

• Dyspnea (shortness of breath) — common and often transient
• Bleeding, bruising, or prolonged bleeding time
• Increased uric acid levels, potential gout flare
• Dizziness, headache, nausea

Precautions & Interactions

• Contraindicated in patients with active bleeding, history of hemorrhagic stroke, or severe liver impairment.
• Avoid concomitant use with strong CYP3A4 inhibitors (e.g. ketoconazole, grapefruit juice) or inducers (e.g. rifampicin). 
• May increase plasma concentrations of P‑gp substrates such as digoxin and ciclosporin.
• Avoid high-dose aspirin (>100 mg/day) in dual antiplatelet therapy due to increased bleeding risk. 
• Use caution with statins—co-administration may slightly increase risks of myopathy. 

Why Choose Ticasprin?

• Generic equivalent to Ticagrelor (Ticaspan®) widely available at competitive pricing in India. 
• Proven antiplatelet efficacy equivalent to innovator drug, including combination with aspirin. 
• Suitable for dual antiplatelet therapy in ACS and post‑stent settings.

Frequently Asked Questions (FAQs)

1. What is Ticasprin 90 mg used for?

Prevention of clot-related cardiovascular events such as heart attack, stroke, and stent thrombosis in patients with ACS or coronary artery disease. 

2. How should it be taken?

Take orally twice daily (90 mg), with or without food. Often prescribed with low-dose aspirin. Follow the dosing schedule advised by your physician. 

3. What if I miss a dose?

Take it as soon as remembered if not too close to your next scheduled dose. Do not double the dose. Skip and continue regular dosing otherwise.

4. Can it cause shortness of breath?

Yes—dyspnea occurs in some patients. It is usually mild to moderate and resolves with time; consult your doctor if it is persistent.

5. Is it safe during pregnancy or breastfeeding?

Not recommended during pregnancy or while breastfeeding unless clearly indicated and supervised by a physician.