Buy Ranx 500 mg (Ranolazine ER) – For People With Chronic Stable Angina

Ranx 500 mg is an extended‑release formulation of ranolazine, indicated for patients with chronic stable angina whose symptoms persist despite standard therapies (e.g., beta‑blockers, nitrates, calcium channel blockers).

How It Works

Ranolazine inhibits the late sodium current in heart muscle cells, reducing intracellular calcium overload and lowering myocardial oxygen demand. It also inhibits potassium channels (hERG), which may cause QT prolongation in some patients.

Uses & Benefits

• Used as add‑on therapy for chronic stable angina when conventional treatments are inadequate.
• Improves exercise tolerance and reduces angina frequency. Not intended for acute chest pain relief.

Dosage & Administration

• Typically starts at 500 mg twice daily (morning and evening), with or without food.
• May be increased to 1000 mg twice daily based on clinical response and tolerability. Treatment adjustments needed if combined with CYP3A inhibitors like diltiazem, verapamil, or erythromycin. Do not exceed 500 mg BID with moderate inhibitors. 
• Swallow tablets whole—do not crush or chew. Missed dose: take when remembered or skip if near next dose—do not double up.

Side Effects & Safety Considerations

• Common: constipation, headache, nausea, dizziness, dry mouth—mostly mild and transient.
• Uncommon or rare: peripheral edema, hypotension, syncope, QT prolongation, fatigue, visual disturbances, allergic reactions—report severe symptoms immediately.
• Contraindicated in moderate-to-severe liver impairment; use cautiously in advanced kidney disease. Do not use in pregnancy or children. 

Precautions & Interactions

• Avoid grapefruit and grapefruit juice—can significantly increase drug levels. 
• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): contraindicated. Moderate inhibitors (e.g., diltiazem, erythromycin): limit dose to 500 mg BID. CYP3A4 inducers (rifampin, phenobarbital) reduce efficacy.Ranolazine inhibits CYP2D6 and P-gp, raising levels of drugs such as metoprolol, digoxin, and statins—dose adjustments may be necessary.
• QT prolongation risk is higher with low potassium/magnesium, bradycardia, or concurrent QT-prolonging drugs. Monitor ECG if indicated. 

Prescription Info & Global Availability

Ranx 500 mg is a prescription-only medication, manufactured by Unichem Laboratories (India). Available internationally through licensed pharmacies with discreet packaging and tracked delivery. Continuous medical oversight advised.

📌 Frequently Asked Questions (FAQs)

1. What does Ranx 500 mg treat?

Ranx is used to reduce angina frequency in adults with chronic stable angina, especially when other anti-anginal medications are insufficient. It is not approved for acute chest pain relief. 

2. What is the typical dosing plan?

Start with 500 mg twice daily. It may be increased to 1000 mg twice daily based on tolerance. Dose should be reduced with moderate CYP3A inhibitors. Do not crush or double doses. 

3. What side effects might I experience?

Common side effects include constipation, headache, nausea, and dizziness—usually mild. Rare serious effects include QT prolongation, fainting, or swelling. Consult your doctor if you experience those. 

4. Can I take it with grapefruit juice or other medications?

No—grapefruit increases ranolazine blood levels. Strong CYP3A4 inhibitors are contraindicated. Moderate inhibitors require dose adjustments. Ranx may interact with CYP2D6 substrates like metoprolol, digoxin, and statins.

5. Is Ranx safe for all patients?

Not for children, pregnant women, or patients with significant liver impairment. Elderly and those with kidney disease require dose caution and regular ECG monitoring.