Clofi 50 mg (Clomiphene) – Product Overview

Clofi 50 mg is a prescription tablet that contains clomiphene citrate, a selective estrogen receptor modulator used to treat female infertility. Produced by Sunrise Remedies Pvt Ltd, each strip holds ten film‑coated tablets delivering a precise 50 mg dose. The product is indicated for women who do not ovulate regularly because of polycystic ovary syndrome, primary ovarian failure, or other hormonal imbalances. Clofi is offered in pack sizes of 30, 60, or 90 tablets, allowing clinicians to tailor treatment length. The formulation complies with Indian regulatory standards and is distributed through licensed pharmaceutical channels worldwide.

What Is Clofi 50 mg?

Clofi belongs to the class of non‑steriodal selective estrogen receptor modulators (SERMs). It works by blocking estrogen receptors in the hypothalamus, which reduces negative feedback on the pituitary gland. This prompts an increase in gonadotropin‑releasing hormone (GnRH), leading to higher secretion of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH). The resulting hormonal surge promotes the growth and maturation of ovarian follicles, and ultimately triggers ovulation when the dominant follicle releases an egg. Each Clofi tablet provides 50 mg of clomiphene citrate, a dose that has been studied extensively for ovulation induction.

Uses and Benefits

The primary clinical use of Clofi 50 mg is to induce ovulation in women with irregular or absent menstrual cycles. Physicians often start with a low daily dose for five days early in the menstrual cycle and may increase the dose in subsequent cycles if ovulation does not occur. Clofi offers several advantages: it is taken orally, costs less than injectable gonadotropins, and has a well‑characterized safety profile when monitored. In assisted‑reproductive settings, Clofi can be combined with intrauterine insemination (IUI) or in‑vitro fertilization (IVF) to improve pregnancy rates. Patients frequently report more regular periods and higher chances of conception after several treatment cycles.

How It Works

Clomiphene citrate functions as a competitive antagonist at estrogen receptors in the hypothalamus and pituitary gland. By blocking estrogen’s inhibitory effect, Clofi stimulates the release of gonadotropin‑releasing hormone (GnRH), which in turn prompts the anterior pituitary to secrete increased amounts of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH). Elevated LH triggers the final maturation of the dominant ovarian follicle, while higher FSH supports the development of multiple follicles, especially in women with polycystic ovary syndrome. Approximately 24–36 hours after the LH surge, the mature follicle releases an oocyte, resulting in ovulation. This mechanistic pathway makes Clofi an effective oral agent for ovulation induction.

Dosage Guidelines

The recommended starting dose of Clofi 50 mg is one tablet taken daily for five consecutive days, usually beginning on the third to fifth day of the menstrual cycle. If ovulation does not occur, a healthcare provider may increase the dose to two tablets daily in the next cycle, with a maximum recommended daily dose of 150 mg (three tablets) under strict medical supervision. Treatment is generally limited to a maximum of six cycles to reduce the risk of ovarian hyperstimulation and endometrial changes. Patients should not adjust the dose on their own and must follow the prescribing clinician’s schedule. For detailed dosing algorithms, refer to the product’s prescribing information or consult a qualified fertility specialist.

Storage and Handling

Clofi 50 mg tablets should be stored at room temperature, away from moisture and direct sunlight, in their original packaging until use. Each strip is sealed to protect the tablets from humidity, which can compromise potency. Patients must keep the medication out of reach of children and pets, and should not use tablets that appear discolored or damaged. Proper disposal of unused medication should follow local regulations to prevent environmental contamination.

Side Effects

Most individuals tolerate Clofi 50 mg with mild, transient side effects such as hot flashes, abdominal discomfort, breast tenderness, nausea, and occasional visual disturbances like blurred vision. Less common but clinically important adverse events include ovarian hyperstimulation syndrome (OHSS), which may present with rapid weight gain, shortness of breath, and pelvic pain, and the formation of ovarian cysts. Rarely, patients experience thromboembolic events or elevated liver enzymes. If any severe or persistent symptoms arise, discontinue use and seek immediate medical attention. For an exhaustive list of side effects, consult the MedlinePlus entry on clomiphene.

Warnings and Precautions

Clofi is contraindicated in patients with known hypersensitivity to clomiphene citrate, significant hepatic disease, unexplained uterine bleeding, or ovarian cysts unrelated to polycystic ovary syndrome. Prior to initiation, a comprehensive evaluation including pelvic examination, hormonal assays, and, when indicated, imaging should be performed. The medication must not be used during pregnancy, as fetal exposure can lead to abnormal male genital development. Concomitant use of certain estrogen‑antagonists or aromatase inhibitors may alter the drug’s efficacy and should be reviewed with a clinician. Proper storage in a dry, temperature‑controlled environment preserves tablet stability. Patients who have a history of thromboembolic disorders or who are undergoing treatment for estrogen‑dependent tumors should discuss alternative fertility options with their physician before starting Clofi. Regular monitoring of ovarian size and endometrial thickness via ultrasound is recommended during treatment cycles to detect early signs of overstimulation. For official safety information, see the FDA prescribing details.

Frequently Asked Questions

1. How long does it take for Clofi 50 mg to induce ovulation? Ovulation typically occurs 24 to 36 hours after the LH surge, which is generally triggered 6 to 12 days after the final dose of Clofi, depending on individual hormone levels and response.
2. Can Clofi be taken together with other fertility drugs? Yes, Clofi is often combined with agents such as gonadotropins or aromatase inhibitors in controlled ovarian stimulation protocols, but such combinations must be supervised by a fertility specialist to avoid overstimulation.
3. Is Clofi safe for women with polycystic ovary syndrome? Clinical studies support its use in PCOS patients when liver function is normal and no contraindications exist; however, some PCOS patients may require dose adjustments or alternative ovulation agents.
4. What should I do if I miss a scheduled dose? If a dose is missed, do not double up; simply skip the missed tablet and resume the regular dosing schedule on the next day.
5. Are there any dietary restrictions while using Clofi? No specific dietary limitations are required, though maintaining adequate hydration and a balanced diet supports overall reproductive health. For more information, see the Wikipedia page on clomiphene.

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