Susten SR 400 mg

Product Overview

Susten SR 400 mg is a sustained‑release tablet formulated by Sun Pharmaceutical Industries Ltd. It delivers a controlled dose of progesterone, a key steroid hormone involved in regulating the menstrual cycle and supporting early pregnancy. The product is packaged as 10 tablets per strip and is available in three pack sizes: 30, 60, or 90 tablets. This medication is specifically indicated for women experiencing female infertility and for use in hormone replacement therapy when prescribed by a qualified healthcare professional.

What is Susten SR 400 mg

The active ingredient in Susten SR 400 mg is progesterone, a synthetic analogue that mimics the natural hormone produced by the ovaries. The sustained‑release (SR) formulation ensures a slow and steady release of the drug over several hours, maintaining stable blood levels and reducing the frequency of dosing. This tablet is classified under female infertility and hormone replacement therapy categories and is manufactured to meet stringent pharmaceutical quality standards.

Uses and Benefits

Susten SR 400 mg is primarily used to support the luteal phase in assisted reproductive technologies, helping to thicken the endometrial lining and improve implantation chances. In hormone replacement therapy, it can alleviate symptoms related to estrogen deficiency, such as hot flashes and mood changes, when combined with appropriate estrogen regimens. Clinical studies have shown that adequate progesterone supplementation can increase pregnancy rates in women undergoing IVF and can reduce the risk of miscarriage associated with luteal phase deficiency.

How It Works

Progesterone exerts its effects by binding to intracellular progesterone receptors, which then translocate to the nucleus and modulate gene expression. In the reproductive system, this leads to preparation of the uterine lining for embryo implantation and maintenance of early pregnancy. The sustained‑release technology of Susten SR 400 mg ensures a gradual increase in serum progesterone, avoiding peaks that could cause side effects, and provides a more physiologic hormone profile compared with immediate‑release formulations.

Dosage Guidelines

Dosage of Susten SR 400 mg must be individualized based on the patient’s medical condition, response to therapy, and the prescribing physician’s assessment. Typical regimens involve taking one tablet daily, preferably at the same time each day, with or without food as directed. Patients should follow the exact dosing schedule provided on the prescription label and should not adjust the dose without consulting their healthcare provider. Adjustments may be made based on serum hormone levels and clinical response.

Side Effects

Like all medications, Susten SR 400 mg can cause adverse effects. Commonly reported side effects include mild abdominal discomfort, bloating, headache, and transient mood changes. Less frequent but more serious reactions may involve allergic skin rashes, breast tenderness, or signs of thromboembolic events such as calf pain or shortness of breath. If any unexpected symptoms occur, patients should contact their physician promptly. For a comprehensive list of side effects, refer to the product’s prescribing information.

Warnings and Precautions

Susten SR 400 mg should be used only under medical supervision. It is contraindicated in patients with known hypersensitivity to progesterone or any component of the tablet formulation. Women with a history of hormone‑sensitive cancers, severe liver disease, or unexplained vaginal bleeding should discuss risks with their doctor before starting therapy. The medication may interact with certain drugs, including certain anticonvulsants and herbal supplements that affect liver enzymes. Patients should inform their healthcare provider of all medications and supplements they are taking.

Frequently Asked Questions

1. What is the difference between Susten SR 400 mg and immediate‑release progesterone?

   The SR (sustained‑release) formulation provides a gradual release of the hormone over several hours, maintaining steadier blood levels and reducing the need for multiple daily doses compared to immediate‑release versions.

2. Can Susten SR 400 mg be used during pregnancy?

   Once pregnancy is confirmed, continued use should be guided by a physician. In some protocols, progesterone supplementation is maintained early in pregnancy to support the uterine environment, but the decision is individualized.

3. Is a prescription required to purchase Susten SR 400 mg?

   Yes, Susten SR 400 mg is a prescription‑only medication. It should be obtained through a licensed pharmacy after a qualified healthcare professional evaluates the patient’s condition.

4. How should the tablet be stored?

   Store the tablets at room temperature, away from moisture and heat. Keep the strip sealed until ready to use and out of reach of children.

5. Where can I find more scientific information about progesterone therapy?

   For evidence‑based details, you can explore resources such as the NIH PubMed Health or the U.S. Food and Drug Administration.

Understanding the proper use, benefits, and safety considerations of Susten SR 400 mg empowers patients to make informed decisions in consultation with their healthcare providers. Always adhere to the guidance of your prescribing clinician and discuss any concerns before making changes to your medication regimen.

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