Progesterone 200 mg Injection (Generic)

Product Overview

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Progesterone 200 mg Injection is a sterile, aqueous solution formulated for intramuscular or subcutaneous administration. Each ampule or vial delivers a precise 200 mg dose of micronized progesterone, a natural steroid hormone essential for regulating the menstrual cycle and supporting early pregnancy. The product is supplied by Sun Pharmaceutical Industries Ltd, a WHO‑GMP certified manufacturer with a global reputation for quality. Pack sizes of 5, 10, or 15 ampules/vials provide flexibility for clinical practice. The medication is indicated for the treatment of female infertility and as part of hormone replacement therapy in selected cases. Storage requires refrigeration at 2 °C to 8 °C, and the solution should be inspected for clarity before use.

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What is Progesterone 200 mg Injection

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Progesterone is a steroid hormone produced in the ovary, placenta, and adrenal glands. In clinical practice, synthetic micronized progesterone is used to supplement low luteal phase levels or to support endometrial receptivity during assisted reproductive technologies. The 200 mg injectable formulation provides a high‑dose, long‑acting release that can be administered weekly or as directed by a physician. Micronization improves bioavailability by reducing particle size, allowing consistent absorption after injection. This medication is classified as a prescription drug and must be ordered through licensed pharmacy channels. For detailed pharmacologic data, refer to the National Institutes of Health’s database on steroid hormones: National Institutes of Health.

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Uses and Benefits

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The primary clinical use of Progesterone 200 mg Injection is to correct luteal phase deficiency, a condition that can impair implantation and early pregnancy maintenance. In hormone replacement regimens, progesterone supports the endometrium when estrogen therapy is prescribed for menopausal symptoms, reducing the risk of endometrial hyperplasia. Physicians also prescribe the injectable form for patients who require rapid hormone level adjustment, such as in cases of severe amenorrhea or in vitro fertilization protocols. Benefits include improved chances of conception, stabilized menstrual cycles, and better symptom control in selected hormone‑sensitive conditions. Properly administered therapy has been shown in clinical trials to increase live‑birth rates when combined with ovulation induction agents. Evidence supporting these outcomes can be reviewed through the FDA’s drug labeling resources: U.S. Food and Drug Administration.

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How It Works

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After intramuscular injection, progesterone is absorbed into the systemic circulation and binds to intracellular progesterone receptors located in endometrial, breast, and reproductive tissues. This interaction modulates gene transcription, leading to increased production of proteins that prepare the uterine lining for embryo implantation. The hormone also exerts negative feedback on the hypothalamic‑pituitary‑gonadal axis, helping to regulate ovarian hormone output. Because the formulation uses micronized particles, the absorption profile is more predictable than with oral tablets, resulting in steadier serum concentrations over several days. The sustained release supports a stable hormonal environment, which is critical for maintaining pregnancy in the first trimester and for synchronizing treatment cycles in assisted reproduction. For a scientific overview, see the MedlinePlus entry on progesterone: MedlinePlus.

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Dosage Guidelines

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Dosage of Progesterone 200 mg Injection is individualized based on the therapeutic goal and patient response. For luteal phase support, a typical regimen involves one 200 mg intramuscular injection every 2 to 3 days during the first 10 weeks of gestation, after which oral or vaginal supplementation may be transitioned. In hormone replacement therapy for menopausal patients, the usual schedule is one injection weekly, often combined with estrogen therapy. Prior to administration, the ampule or vial should be inspected for particulate matter and stored at 2 °C to 8 °C; once opened, the solution must be used promptly. Dose adjustments may be required in patients with hepatic impairment or those taking medications that affect hormone metabolism. Always follow the prescribing clinician’s instructions and retain the product label for reference.

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Side Effects

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Like all hormonal medications, Progesterone 200 mg Injection can produce side effects, although many are mild and transient. Common reactions include pain or irritation at the injection site, mild dizziness, and temporary breast tenderness. Less frequently, patients may experience headaches, nausea, or fluid retention, which usually resolve without intervention. Rare but serious adverse events include severe allergic reactions, venous thromboembolic events, or marked mood changes; these require immediate medical attention. Patients should be monitored for signs of hyperglycemia, especially if they have diabetes, and should report any unexpected bleeding or spotting to their healthcare provider. A comprehensive safety profile is documented by the manufacturer and can be accessed through the FDA’s adverse event reporting system: FDA Safety Reports.

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Warnings and Precautions

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Progesterone 200 mg Injection is contraindicated in individuals with known hypersensitivity to the product or any of its excipients. It should not be used in patients with active liver disease, unexplained vaginal bleeding, or a history of thromboembolic disorders unless specifically directed by a physician. Caution is advised in lactating women, as the hormone may pass into breast milk, and in patients with uncontrolled hypertension. Prior to initiation, a thorough medical history and baseline laboratory tests, including liver function and lipid profile, are recommended. The medication must be kept out of reach of children and stored in a refrigerated environment; freezing must be avoided as it may alter the formulation. If a dose is missed, the patient should not double up on injections but contact their clinician for guidance. For detailed prescribing information, consult the product’s official label or a licensed pharmacist.

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Frequently Asked Questions

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What condition does Progesterone 200 mg Injection treat?

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It is primarily prescribed for luteal phase deficiency, a hormonal imbalance that can impair implantation and early pregnancy. The medication is also used as part of hormone replacement therapy in selected menopausal or fertility treatment protocols, helping to stabilize the endometrial lining and support reproductive health.

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How often should the injection be administered?

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Typical dosing schedules involve a 200 mg intramuscular injection every two to three days during the first ten weeks of fertility treatment, or once weekly when used for hormone replacement therapy. The exact frequency is determined by the prescribing clinician based on individual response and therapeutic goals.

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Can the injection be self‑administered at home?

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Self‑administration is possible only after a healthcare professional has demonstrated proper technique and confirmed that the patient is comfortable with injections. The medication must be stored refrigerated and used within the time frame indicated on the label. Patients should always follow the instructions provided by their prescriber and seek training before using the product outside a clinical setting.

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Is the medication safe during pregnancy?

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When used under medical supervision, progesterone supplementation is considered safe and is commonly administered to support early pregnancy in cases of luteal phase deficiency. However, it should not be used indiscriminately, and the treating physician must evaluate each patient’s history, including any prior adverse reactions, before continuing therapy throughout gestation.

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Where can I obtain Progesterone 200 mg Injection?

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The injectable formulation is dispensed by licensed pharmacies upon presentation of a valid prescription. It is distributed through authorized medical suppliers and can be ordered online from verified pharmaceutical platforms that comply with local regulatory standards. Always verify the seller’s credentials and ensure the product’s integrity before purchase.

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