Product Overview

Progesterone 200 mg is a synthetic form of the natural hormone progesterone. It is manufactured by Sanzyme Biologics (P) Ltd and is supplied in strengths of 200 mg per soft gelatin capsule. Packaging options include 10 capsules per strip, with bulk packs of 100, 200, or 300 capsules available for commercial use. The product is indicated for the management of female infertility and as part of hormone replacement therapy. Delivery typically takes between 6 and 15 days after order confirmation. This generic formulation meets the same quality standards as branded equivalents and is listed on major pharmacy platforms.

What is Progesterone 200 mg

Progesterone is a steroid hormone that prepares the uterine lining for implantation and supports early pregnancy. In clinical practice, oral progesterone capsules are used to supplement low hormone levels in women experiencing infertility or menopausal symptoms. The 200 mg dosage provides a consistent daily amount that can be titrated based on patient response. Scientific literature, such as reviews from the National Institutes of Health, describes progesterone as essential for regulating menstrual cycles and maintaining placental health. This generic version contains the same active ingredient as more expensive brand products, offering an affordable option for long‑term therapy.

Uses and Benefits

The primary uses of Progesterone 200 mg include ovulation induction support, luteal phase support after assisted reproductive technologies, and as part of hormone replacement regimens for women with low progesterone levels. Benefits reported in clinical studies include improved endometrial receptivity, increased pregnancy rates when combined with estrogen therapy, and relief of menopausal hot flashes when estrogen is also prescribed. Because the capsules are soft gelatin, they are easy to swallow and provide a steady release of hormone over several hours. Patients often appreciate the convenience of a once‑daily dose and the availability of multiple pack sizes to suit individual treatment plans.

How It Works

After oral ingestion, progesterone is absorbed from the gastrointestinal tract and binds to intracellular progesterone receptors in endometrial cells. This interaction triggers gene transcription that promotes secretory changes in the uterine lining, making it more receptive to embryo implantation. The hormone also modulates immune responses to prevent rejection of the fetus and helps maintain pregnancy until the placenta takes over steroidogenesis. Pharmacokinetic studies show that peak serum concentrations occur within two to three hours, with a half‑life of approximately 15 hours, allowing once‑daily dosing. The steady‑state levels achieved with continuous use are sufficient to sustain the endometrial environment for up to 14 days.

Dosage Guidelines

Typical dosing for female infertility involves one capsule taken daily, usually in the evening, beginning on the day of ovulation or after embryo transfer. For hormone replacement therapy, the dose may be adjusted based on the patient’s menopausal symptom profile and serum hormone levels. Physicians often prescribe a cyclic schedule — 10 to 14 days of progesterone followed by a break of several days — depending on the specific regimen. It is important to follow the prescribing clinician’s instructions and not to exceed the recommended daily amount. Patients should store capsules at room temperature, away from moisture and direct sunlight, and keep the strip sealed until use.

Side Effects

Most individuals tolerate progesterone 200 mg well, but some may experience mild adverse effects. Common side effects include bloating, breast tenderness, headache, and mild nausea. Less frequent effects can involve mood changes, dizziness, or temporary weight gain due to fluid retention. Rare but serious reactions such as allergic skin rash, severe abdominal pain, or visual disturbances require immediate medical attention. If side effects persist beyond a few days or become bothersome, patients should contact their healthcare provider for dose adjustment or alternative therapy. For more detailed safety data, see the National Institutes of Health.

Warnings and Precautions

Progesterone therapy is contraindicated in patients with active liver disease, unexplained vaginal bleeding, or a history of hormone‑sensitive cancers. It should not be used during pregnancy unless specifically prescribed for luteal support, and caution is advised for nursing mothers. Drug interactions may occur with medications that induce cytochrome P450 enzymes, potentially reducing progesterone levels. Patients should inform their doctor of all current medications, including over‑the‑counter supplements. Regular monitoring of blood pressure and liver function tests is recommended during prolonged treatment. For official prescribing information, refer to the FDA and MedlinePlus.

Frequently Asked Questions

What is the recommended starting dose for infertility treatment?

The usual starting dose is one 200 mg capsule taken daily, typically in the evening, beginning on the day of ovulation or shortly after embryo transfer. Your physician may adjust the dose based on response.

Can progesterone capsules be taken with food?

Yes, the soft gelatin capsules can be taken with or without food. However, taking them with a light meal may reduce the chance of stomach upset in sensitive individuals.

How long should I continue progesterone therapy?

Duration varies by indication. For luteal phase support, therapy is usually continued for 12 to 14 days after ovulation. In hormone replacement regimens, the course may be longer and is determined by your healthcare provider.

Is it safe to use progesterone while trying to conceive?

When prescribed for luteal support, progesterone is considered safe and does not interfere with conception efforts. However, it should only be used under medical supervision.

Where can I find more detailed prescribing information?

Comprehensive prescribing details are available on the FDA’s drug label database and through the National Center for Biotechnology Information’s PubChem entry for progesterone.

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