Product Overview

Progesterone 300 mg is a pharmaceutical-grade oral capsule formulated to support women experiencing hormonal imbalances related to female infertility and menopausal symptoms. Manufactured by Sun Pharmaceutical Industries Ltd, each strip contains ten soft gelatin capsules that dissolve quickly for optimal absorption. The product is indicated for use under medical supervision as part of hormone replacement therapy (HRT) or as an adjunct in assisted reproductive techniques. Packaged in strengths of 30, 60, or 90 capsules, the medication offers flexible dosing options while maintaining a consistent 300 mg progesterone dose per capsule. Its synthetic progesterone activity mimics the natural hormone’s role in regulating the menstrual cycle, preparing the endometrium, and supporting early pregnancy.

What is Progesterone 300 mg

Progesterone is a steroid hormone produced naturally in the ovaries, placenta, and adrenal glands. In clinical practice, a synthetic analogue is administered to supplement low progesterone levels that can impede implantation or maintain a healthy pregnancy. The 300 mg strength provides a standardized dose that aligns with prescribing recommendations for adult women who require pharmacologic support. Unlike lower-dose oral progesterone, the 300 mg formulation is designed for once‑daily administration, delivering a therapeutic plasma concentration that sustains luteal phase support. The capsule’s soft gelatin coat protects the active ingredient from gastric degradation, ensuring reliable bioavailability.

Uses and Benefits

Clinicians prescribe Progesterone 300 mg primarily to address luteal phase deficiency, a condition where insufficient progesterone compromises endometrial receptivity. In assisted reproductive technology (ART), the medication is used for luteal phase support after embryo transfer, improving implantation rates. For hormone replacement therapy, it is combined with estrogen to alleviate vasomotor symptoms and protect the uterine lining from estrogen‑induced hyperplasia. Additional benefits include regulation of irregular menstrual cycles, reduction of endometrial thickness variability, and support in cases of recurrent miscarriage associated with hormonal insufficiency. The medication’s consistent potency and oral convenience make it a practical option for long‑term management under physician guidance.

How It Works

Progesterone exerts its effects by binding to intracellular progesterone receptors, modulating gene transcription that governs uterine preparedness and immune tolerance. Once absorbed, the compound travels systemically, supporting the secretory transformation of the endometrium and suppressing uterine contractility. In reproductive applications, adequate progesterone levels signal the brain to maintain luteal function, thereby extending the window of fertility. The drug’s pharmacodynamics are characterized by a gradual rise in serum concentrations, peaking within two to three hours post‑dose, followed by a controlled decline that mirrors the natural hormone’s diurnal pattern. This physiological mimicry facilitates seamless integration with the body’s endocrine axis.

Dosage Guidelines

The recommended adult dosage for fertility support typically involves one 300 mg capsule taken orally once daily, preferably in the evening, for a minimum of 10 days following ovulation or embryo transfer. For hormone replacement therapy, the same dosing schedule may be continued cyclically, with treatment durations individualized according to clinical response. Patients should not exceed the prescribed duration without medical reassessment. Dosage adjustments are rarely necessary for renal or hepatic impairment, but caution is advised in elderly patients with comorbidities. It is essential to swallow the capsule whole; crushing or chewing may alter release characteristics and reduce efficacy. Always verify the prescribed strength before each refill. Regular laboratory monitoring, including serum progesterone levels and endometrial thickness via ultrasound, is recommended to assess treatment response and adjust therapy if needed. Patients should schedule follow‑up visits every 2‑3 weeks during the initial treatment phase, and then at intervals determined by their clinician. Documentation of any breakthrough bleeding or changes in symptoms should be reported promptly, and may influence dosing decisions for subsequent cycles overall and may influence dosing decisions for subsequent cycles overall.

Side Effects

Like all hormonal agents, Progesterone 300 mg may produce adverse effects, though most are mild and transient. Common reactions include abdominal cramping, breast tenderness, headache, and mild nausea. Less frequent but clinically significant events comprise mood alterations, dizziness, and breakthrough bleeding. Rarely, patients experience thromboembolic phenomena, necessitating immediate discontinuation and medical evaluation. Long‑term safety data indicate a low incidence of cardiovascular complications when used appropriately, yet clinicians should monitor blood pressure and lipid profiles periodically. If any severe or persistent side effect arises, contact a healthcare professional promptly to discuss dose modification or alternative therapy.

Warnings and Precautions

Progesterone 300 mg is contraindicated in individuals with known hypersensitivity to the active ingredient or any excipients, as well as in patients with active liver disease, unexplained vaginal bleeding, or a history of thromboembolic disorders. Pregnant women should only use the medication under strict medical supervision, as excessive supplementation may interfere with natural hormonal signaling. Caution is warranted in patients with uncontrolled hypertension, severe migraine, or epilepsy. Drug interactions may occur with cytochrome P450 inducers or inhibitors; therefore, a complete medication review is essential before initiating therapy. Store the capsules in a cool, dry place away from direct sunlight and keep out of reach of children.

Frequently Asked Questions

Q: How long should I take Progesterone 300 mg after embryo transfer? A: Clinical protocols generally recommend continuing the capsule for 10 to 14 days post‑transfer, after which a pregnancy test is performed; if positive, your physician may adjust the regimen. For detailed guidance, refer to the FDA luteal phase support recommendations.

Q: Can I combine Progesterone 300 mg with other fertility medications? A: Yes, it is commonly paired with estrogen or GnRH antagonists in IVF cycles, but dosage interactions must be monitored; consult your specialist. Additional safety information is available from MedlinePlus.

Q: Is Progesterone 300 mg safe during breastfeeding? A: Current data suggest minimal excretion into breast milk, yet the American College of Obstetricians and Gynecologists advises caution; discuss with your provider. For more on lactation safety, see the NIH hormone and lactation page.

Q: What should I do if I miss a dose of Progesterone 300 mg? A: Take the missed capsule as soon as you remember, unless it is almost time for the next scheduled dose; then skip the missed one and resume your regular schedule. Avoid doubling up. The FDA label provides further details.

Q: Are there any dietary restrictions while using Progesterone 300 mg? A: No specific foods need to be avoided; however, maintain a balanced diet and limit excessive alcohol intake, which may affect hormone metabolism. General precautions are outlined on Drugs.com.

Related Products

• Famotidine 20mg (Generic)
• Omesec 20 mg (Omeprazole)
• Pantocid DSR (Pantoprazole/Domperidone)
• Famotidine 40mg (Generic)
• Famocid 20mg (Famotidine)
• Famocid 40mg (Famotidine)
• Famocid (Famotidine)
• Supatret 0.04% Gel (Tretinoin)
• Supatret 0.1% Gel (Tretinoin)
• Supatret C Gel (Clindamycin/Tretinoin)
• Supatret Gel (Tretinoin)
• Acitretin 25mg (Generic)