Susten 400 mg (Progesterone)

Product Overview

Susten 400 mg is a pharmaceutically formulated micronized progesterone capsule produced by Sun Pharmaceutical Industries Ltd. Each strip contains ten soft gelatin capsules, each delivering a precise 400 mg dose of progesterone. The product is indicated for the treatment of female infertility and as part of hormone replacement therapy in selected patient populations. Packaged in a convenient 10‑capsule strip, Susten is designed for easy administration and reliable absorption. The medication is supplied in strengths of 400 mg per capsule and is available in pack sizes of 30, 60, and 90 capsules to accommodate varying treatment durations. Shipping typically takes between six and fifteen days, depending on the destination.

What Is Susten 400 mg (Progesterone)

Progesterone is a steroid hormone that plays a central role in regulating the menstrual cycle, preparing the uterine lining for implantation, and maintaining early pregnancy. Susten contains micronized progesterone, a form that has been processed to enhance bio‑availability when taken orally. The 400 mg strength is commonly used in clinical practice for hormone replacement regimens and for supporting luteal phase function in women experiencing difficulty conceiving. As an FDA‑registered active ingredient, progesterone is listed on authoritative databases such as the NIH’s PubChem database and MedlinePlus, underscoring its recognized therapeutic value.

Uses and Benefits

Susten 400 mg is prescribed primarily to address two clinical scenarios: (1) female infertility associated with luteal phase deficiency, and (2) hormone replacement therapy in post‑menopausal women who require progesterone supplementation. In infertility treatment, the capsule supports the endometrial lining, increasing the likelihood of successful implantation after assisted reproductive techniques or timed intercourse. In hormone replacement therapy, it helps balance estrogen therapy, reducing the risk of endometrial hyperplasia. Patients often report more regular menstrual cycles, improved pelvic comfort, and a sense of hormonal stability when the medication is used as directed.

How It Works

The active ingredient, micronized progesterone, mimics the natural hormone produced by the corpus luteum in the ovary. After oral ingestion, the micronized particles are absorbed through the gastrointestinal tract and converted to active metabolites that bind to progesterone receptors in the endometrium. This binding promotes secretory changes in the uterine lining, making it more receptive to embryo implantation. Additionally, progesterone exerts feedback inhibition on the hypothalamic‑pituitary axis, helping to regulate ovulatory cycles. The soft gelatin capsule formulation is designed to protect the medication from gastric degradation, ensuring a consistent dose reaches systemic circulation. For more information on progesterone physiology, see the NIH’s overview: Progesterone Function.

Dosage Guidelines

Standard dosing for Susten 400 mg is one capsule taken once daily, typically at bedtime, to align with the body’s natural circadian rhythm and reduce gastrointestinal discomfort. The exact regimen may vary based on the individual’s medical condition, response to therapy, and the prescribing physician’s evaluation. Patients are advised to follow the dosage instructions on the prescription label and to discuss any missed doses with their healthcare provider. It is important not to exceed the recommended dose, and to store the capsules at room temperature away from moisture and heat. For comprehensive dosing information, refer to the product’s prescribing information or consult a qualified clinician.

Side Effects

Like all pharmaceutical products, Susten 400 mg may cause adverse effects, although many users experience none or only mild symptoms. Common side effects include mild abdominal discomfort, bloating, breast tenderness, and occasional spotting. Less frequent but clinically significant reactions can involve mood changes, dizziness, or allergic skin reactions such as rash or itching. If any side effect persists or worsens, patients should discontinue use and seek medical attention promptly. For a complete list of reported reactions, consult the FDA’s drug label or a pharmacist. Additional safety information is available at MedlinePlus.

Warnings and Precautions

Susten is contraindicated in individuals with a known hypersensitivity to progesterone or any component of the capsule formulation. Patients with a history of thromboembolic disorders, liver disease, or certain types of cancer should discuss potential risks with their physician before initiating therapy. The medication should not be used during pregnancy unless specifically prescribed for luteal support, and it is not intended for use in children. Drug interactions may occur with certain anticonvulsants, glucocorticoids, or hormonal agents; therefore, a full medication review is essential. Always keep the product out of reach of unauthorized persons and store it according to the label instructions. For detailed safety data, refer to the FDA’s prescribing information: FDA.

Frequently Asked Questions

Q: What is the typical treatment duration with Susten 400 mg?
A: The length of therapy depends on the clinical indication and physician guidance. In infertility protocols, treatment often continues for several cycles, while hormone replacement may be ongoing based on patient response.

Q: Can Susten be taken with estrogen therapy?
A: Yes, it is frequently prescribed together with estrogen in combined hormone replacement regimens, but the schedule and dosage should be individualized by a healthcare professional.

Q: Is the capsule suitable for patients with lactose intolerance?
A: The formulation is free of lactose; however, patients with severe allergies should review the inactive ingredient list or consult a pharmacist.

Q: How should the capsules be stored to maintain efficacy?
A: Store at room temperature, away from moisture and direct sunlight. Keep the strip sealed until ready to use.

Q: Where can I verify the medication’s authenticity and regulatory status?
A: Detailed product information and regulatory references are available through the FDA’s drug database, the NIH’s medication library, and MedlinePlus.

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